1-(4-Aminophenyl)piperazine
1-(4-Aminophenyl)piperazine (CAS 67455-41-8) is an aromatic amine and heterocyclic building block with the molecular formula C10H15N3 and a molar mass of 177.25 g/mol. Combining an aniline-type primary amine with an N-arylpiperazine ring, it is a versatile bifunctional intermediate in medicinal and synthetic chemistry. Tech Serve Solutions supplies it at 97% assay as a research-grade reagent for laboratory and process-development use.
- Synonyms
- 1-(4-Aminophenyl)piperazine4-(1-Piperazinyl)aniline4-(Piperazin-1-yl)aniline1-(4-Aminophenyl)piperazine, 97%CAS 67455-41-8
Pharmaceutical intermediate
Serves as a bifunctional scaffold in the synthesis of active pharmaceutical ingredients and drug candidates, where the arylpiperazine motif is a recurring feature. The free aromatic amine enables further functionalisation such as amide and urea formation.
Heterocyclic building block
Used in chemical synthesis as a piperazine building block for constructing more complex nitrogen-containing heterocyclic systems. Both the primary amine and the secondary piperazine nitrogen offer convenient handles for derivatisation.
Diazonium and coupling chemistry
The para-substituted aromatic amine can be diazotised and engaged in azo coupling, Sandmeyer and related transformations, supporting the preparation of dyes, ligands and substituted aromatics.
Research and discovery chemistry
Applied as a reference reagent in laboratory-scale exploratory synthesis, structure-activity studies and method development where a defined arylpiperazine fragment is required.
| Molecular weight | 177.25 |
|---|---|
| Empirical formula | C10H15N3 |
| Assay | 97% |
| Melting point | 119-123 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Aminophenyl)piperazine used for?
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It is used mainly as a building block and intermediate in chemical and pharmaceutical synthesis. The combination of a reactive aromatic primary amine and an N-arylpiperazine ring makes it a useful bifunctional scaffold for preparing more complex nitrogen-containing molecules, including drug candidates and substituted aromatics.
What is the CAS number and molecular formula of 1-(4-Aminophenyl)piperazine?
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The CAS number is 67455-41-8 and the molecular formula is C10H15N3, with a molecular weight of 177.25 g/mol. Its MDL number is MFCD01365906 and the reported melting point is 119-123 °C.
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(4-Aminophenyl)piperazine at a typical assay of 97% as a research and technical grade reagent suitable for laboratory and process-development work. We do not represent this material as USP, BP or EP pharmacopoeia grade. A certificate of analysis can be provided with each batch.
What are the safety and handling requirements?
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The material is classified Danger (GHS05, GHS07) with hazard statements H302 (harmful if swallowed), H315 (causes skin irritation), H318 (causes serious eye damage) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust generation, and work with adequate ventilation. Always consult the Safety Data Sheet before use.
How is 1-(4-Aminophenyl)piperazine packed, shipped and exported?
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It is supplied in securely sealed containers sized to the order quantity, from laboratory packs to bulk, with full labelling and documentation. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international shipping with the relevant SDS and transport paperwork.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for qualification where appropriate.
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