1-(4-Bromo-2-fluorobenzyl)piperazine
1-(4-Bromo-2-fluorobenzyl)piperazine (CAS 870703-75-6) is a halogenated, fluorinated heterocyclic building block with the molecular formula C11H14BrFN2 and a molar mass of 273.14 g/mol. It pairs a secondary piperazine ring with a 4-bromo-2-fluorobenzyl group, giving an aryl bromide and a free N-H amine for onward functionalisation. Supplied at 96% assay, it is used mainly in chemical synthesis as an intermediate for pharmaceutical and discovery research. Tech Serve Solutions supplies and exports it worldwide.
- Synonyms
- 1-(4-Bromo-2-fluorobenzyl)piperazine1-[(4-bromo-2-fluorophenyl)methyl]piperazine4-bromo-2-fluorobenzylpiperazineCAS 870703-75-6MFCD07368744
Pharmaceutical and medicinal-chemistry intermediate
Serves as a piperazine-bearing scaffold in the synthesis of candidate molecules and pharmaceutical intermediates. The substituted benzylpiperazine motif is a common fragment in medicinal-chemistry programmes.
Fluorinated and halogenated building block
The combination of an aromatic fluorine and a bromine substituent makes this a versatile fluorinated building block for introducing controlled steric and electronic effects into target structures.
Cross-coupling substrate
The aryl bromide is a handle for palladium-catalysed cross-coupling reactions such as Suzuki, Buchwald-Hartwig and related transformations, enabling rapid elaboration of the aromatic ring.
Functionalisation through the piperazine nitrogen
The free secondary amine (N-H) of the piperazine ring supports acylation, alkylation, sulfonylation and reductive amination, allowing diverse derivatives to be prepared from a single intermediate.
Discovery and library synthesis
As a defined C11 heterocyclic building block, it is suited to analogue preparation and library synthesis in early-stage research and process-development laboratories.
| Molecular weight | 273.14 |
|---|---|
| Empirical formula | C11H14BrFN2 |
| Assay | 96% |
| Boiling point | 120-122 °C/0.02 mmHg |
| Density | 1.411 g/mL at 25 °C |
| Refractive index | n20/D 1.563 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Bromo-2-fluorobenzyl)piperazine used for?
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It is used mainly as a synthetic intermediate and building block in chemical synthesis. The piperazine ring, free N-H amine and reactive aryl bromide make it useful for pharmaceutical intermediates, cross-coupling chemistry and discovery-scale analogue preparation. Applications outside general organic synthesis should be confirmed for your specific process.
What is the CAS number and molecular formula of 1-(4-Bromo-2-fluorobenzyl)piperazine?
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The CAS number is 870703-75-6 and the molecular formula is C11H14BrFN2, with a molecular weight of 273.14 g/mol. The MDL number is MFCD07368744 and the PubChem Substance ID is 24884307.
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(4-Bromo-2-fluorobenzyl)piperazine at a typical assay of 96% as a research and technical-grade building block. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis is provided with each batch, and reported physical data include a density of 1.411 g/mL at 25 °C and a refractive index of n20/D 1.563.
What are the safety and handling requirements for 1-(4-Bromo-2-fluorobenzyl)piperazine?
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It carries GHS pictogram GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves and eye protection, use suitable respiratory protection and adequate ventilation, and avoid breathing dust (P261); if it contacts the eyes, rinse cautiously with water (P305+P351+P338). It is classified WGK 3 (highly hazardous to water), so prevent release to drains and watercourses. Always consult the Safety Data Sheet before use.
How is 1-(4-Bromo-2-fluorobenzyl)piperazine packed, shipped and exported?
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It is packed in tightly closed, appropriately labelled containers sized from research quantities to bulk, with packaging selected to suit the order and destination. Tech Serve Solutions exports worldwide and supplies full documentation, including a certificate of analysis and Safety Data Sheet, with transport handled in accordance with applicable regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged on request, subject to availability.
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