1,3-Difluoro-2-propanol

CAS 453-13-4FCH2CH(OH)CH2FChemical Synthesis

1,3-Difluoro-2-propanol (CAS 453-13-4) is a fluorinated organic building block with the molecular formula FCH2CH(OH)CH2F and a molecular weight of 96.08 g/mol. This compound serves as a valuable intermediate in chemical synthesis, notably for the preparation of 1,3-difluoroacetone. Supplied at a purity of 99%, it is a key reagent for research and development in organic chemistry, particularly within the pharmaceutical and materials science sectors.

Synonyms: FCH2CH(OH)CH2F

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1,3-Difluoro-2-propanol (FCH2CH(OH)CH2F) — chemical structure, CAS 453-13-4; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Synthesis of 1,3-Difluoroacetone

1,3-Difluoro-2-propanol is documented for its use in the synthesis of 1,3-difluoroacetone. This transformation highlights its utility as a precursor in fluorochemical synthesis.

Fluorinated Building Block

As an organic fluorinated building block, this compound is employed in the creation of more complex fluorinated molecules. Its structure allows for the introduction of difluoropropyl groups into various organic frameworks.

Chemical Synthesis Reagent

The compound functions as a versatile reagent in organic synthesis, enabling chemists to explore novel reaction pathways and develop new chemical entities. Its reactivity is characteristic of a fluorinated alcohol.

02 /Properties

Molecular weight	96.08
Linear formula	FCH2CH(OH)CH2F
Assay	99%
Boiling point	54-55 °C/34 mmHg(lit.)
Density	1.24 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.373(lit.)
Contains / stabiliser	sodium fluoride as stabilizer
Application	1,3-Difluoro-2-propanol was used in the synthesis of 1,3-difluoroacetone1.

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	42 °C / 107.6 °F
Transport (UN / ADR)	UN 1987C 3 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	10-36/37/38
Safety statements (S)	16-26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

453-13-4

MDL number

MFCD00000452

PubChem substance

24850608

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1,3-Difluoro-2-propanol used for?

1,3-Difluoro-2-propanol is primarily used as a chemical intermediate in the synthesis of other compounds, notably 1,3-difluoroacetone. It serves as a fluorinated building block in organic synthesis.

What is the CAS number and formula for 1,3-Difluoro-2-propanol?

The CAS number for 1,3-Difluoro-2-propanol is 453-13-4, and its linear formula is FCH2CH(OH)CH2F.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1,3-Difluoro-2-propanol with an assay of 99% purity. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.

How should 1,3-Difluoro-2-propanol be handled safely?

1,3-Difluoro-2-propanol is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area.

Is 1,3-Difluoro-2-propanol shipped internationally?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and we can arrange for the export of 1,3-Difluoro-2-propanol.

How can I request a quote or sample?

To request a quote or sample of 1,3-Difluoro-2-propanol, please contact our sales team via the website or by telephone, providing your specific requirements.