1,3-Bis(trimethylsilyl)urea
1,3-Bis(trimethylsilyl)urea (CAS: 18297-63-7) is a silylated urea derivative with the linear formula (CH3)3SiNHCONHSi(CH3)3 and a molecular weight of 204.42 g/mol. This compound serves as a versatile building block in organic synthesis. Its primary applications lie in its role as a reagent for introducing silyl or urea functionalities into organic molecules, facilitating various chemical transformations.
- IUPAC
- N,N′-Bis(trimethylsilyl)urea,BSU
- Synonyms
- (CH3)3SiNHCONHSi(CH3)3N,N′-Bis(trimethylsilyl)ureaBSU

Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of complex organic molecules. It can participate in reactions that require protected urea functionalities or silylation.
Reagent for Silylation
Acts as a silylating agent, enabling the protection of functional groups or the modification of molecular structures with trimethylsilyl groups.
Building Block for Heterocycles
Contributes to the construction of novel heterocyclic compounds in medicinal chemistry and materials science research.
| Molecular weight | 204.42 |
|---|---|
| Linear formula | (CH3)3SiNHCONHSi(CH3)3 |
| Assay | 95% |
| Solubility | pyridine: soluble100 mg/mL, clear to slightly hazy, colorless to light yellow |
| Melting point | 219-221 °C(lit.) |

Hazard statements
- H228Flammable solid
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1325 4.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Bis(trimethylsilyl)urea used for?
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1,3-Bis(trimethylsilyl)urea is primarily used as a building block and reagent in organic synthesis, particularly for silylation reactions and the construction of organic molecules.
What is the CAS number and formula for 1,3-Bis(trimethylsilyl)urea?
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The CAS number is 18297-63-7 and the linear formula is (CH3)3SiNHCONHSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,3-Bis(trimethylsilyl)urea with an assay of 95%. This product is not represented as USP, BP, or EP grade.
How should 1,3-Bis(trimethylsilyl)urea be handled safely?
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1,3-Bis(trimethylsilyl)urea is a flammable solid (H228) and must be handled with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and keep away from ignition sources.
How is this chemical packed and shipped?
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This compound is classified as UN 1325, Hazard Class 4.1, Packing Group II. It is carefully packed and exported by Tech Serve Solutions in compliance with international shipping regulations for hazardous materials.
How can I request a quote or sample?
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To request a quote or sample of 1,3-Bis(trimethylsilyl)urea, please contact our sales team through the website or by phone, providing your specific requirements.
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