5-Methoxy-6-(trifluoromethyl)indole
5-Methoxy-6-(trifluoromethyl)indole (CAS: 178896-78-1; Formula: C10H8F3NO; MW: 215.17) is a trifluoromethyl-substituted indole building block. Its structure makes it a valuable intermediate in organic synthesis. This compound is primarily utilised as a reactant in the preparation of specific pharmaceutical agents, notably pyridylcarbamoylindolines with potential as selective 5HT2C/2B receptor antagonists, contributing to advancements in medicinal chemistry.
- IUPAC
- 5-Methoxy-6-trifluoromethyl-1H-indole
- Synonyms
- 5-Methoxy-6-trifluoromethyl-1H-indole
Pharmaceutical Intermediate
Serves as a key reactant in the synthesis of novel pharmaceutical compounds. It is specifically noted for its role in preparing pyridylcarbamoylindolines, which are being investigated as selective antagonists for 5HT2C/2B receptors.
Organic Synthesis Building Block
A versatile building block for constructing complex organic molecules. The presence of the methoxy and trifluoromethyl groups on the indole core offers unique reactivity and properties for further chemical transformations.
Medicinal Chemistry Research
Utilised in research and development within medicinal chemistry to explore new therapeutic agents. Its application in creating receptor antagonists highlights its potential in drug discovery programs targeting neurological or psychiatric conditions.
| Molecular weight | 215.17 |
|---|---|
| Empirical formula | C10H8F3NO |
| Assay | 97% |
| Application | • Reactant for preparation of pyridylcarbamoylindolines as selective 5HT2C/2B receptor antagonists1 |
| Melting point | 104-105 °C |
Hazard statements
- H301Toxic if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P301IF SWALLOWED
- P305IF IN EYES
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Methoxy-6-(trifluoromethyl)indole used for?
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5-Methoxy-6-(trifluoromethyl)indole is primarily used as a reactant in organic synthesis, particularly for preparing pyridylcarbamoylindolines which function as selective 5HT2C/2B receptor antagonists. It is a valuable building block in medicinal chemistry research and drug discovery.
What are the CAS number and molecular formula of 5-Methoxy-6-(trifluoromethyl)indole?
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The CAS number for 5-Methoxy-6-(trifluoromethyl)indole is 178896-78-1, and its molecular formula is C10H8F3NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Methoxy-6-(trifluoromethyl)indole with a minimum purity of 97%. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
How is this chemical handled and what are the safety precautions?
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This compound is classified as acutely toxic if swallowed and causes serious eye irritation (H301-H319). It is labelled with a Danger signal word. Handle with appropriate personal protective equipment, including gloves and eye protection, in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling information and emergency procedures. Follow precautionary statements P301 + P310 and P305 + P351 + P338.
Is this chemical available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 5-Methoxy-6-(trifluoromethyl)indole, serving clients worldwide.
How can I request a sample or quote?
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To request a sample or a quote for 5-Methoxy-6-(trifluoromethyl)indole, please use the contact form on our website or contact our sales department directly.
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