(−)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]ethane

CAS 136779-26-55S)-2Chemical Synthesis

(−)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]ethane (CAS: 136779-26-5) is a chiral phosphine ligand with the molecular formula C14H28P2 and a molecular weight of 258.32 g/mol. It belongs to the BPE class of ligands, renowned for their high efficiency in asymmetric catalysis. This compound is primarily utilised in enantioselective synthesis, facilitating the creation of specific stereoisomers in chemical reactions.

IUPAC: (S,S)-Me-BPE
Synonyms: 5S)-2, 5-dimethylphospholano]ethane(S,S)-Me-BPE

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(−)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]ethane (5S)-2) — chemical structure, CAS 136779-26-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentsDuPhos/BPE

01 /Applications

Asymmetric Catalysis

This ligand is employed as a chiral auxiliary in transition metal-catalyzed reactions to induce enantioselectivity. It is particularly effective in reactions such as asymmetric hydrogenation and allylic alkylation.

Chiral Synthesis

Its unique structure enables the synthesis of enantiomerically pure compounds, which are critical in the pharmaceutical and fine chemical industries. It serves as a key component in producing complex chiral molecules.

Ligand for Metal Complexes

It forms stable complexes with various transition metals, enhancing their catalytic activity and selectivity. These complexes are vital for developing novel synthetic methodologies.

02 /Properties

Molecular weight	258.32
Empirical formula	C14H28P2
Boiling point	64-67 °C/0.06 mmHg
Density	0.938 g/mL at 25 °C
Refractive index	n20/D 1.535
Application	DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

Danger

Hazard statements

H250Catches fire spontaneously if exposed to air

Precautionary statements

P222Do not allow contact with air
P231Handle under inert gas
P422

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Transport (UN / ADR)	UN 2845 4.2
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F
Risk statements (R)	11-17

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136779-26-5

MDL number

MFCD01073771

PubChem substance

24884722

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (S,S)-Me-BPE used for?

This compound is primarily used as a chiral ligand in asymmetric synthesis, particularly in enantioselective catalytic reactions.

What are the CAS number and formula for (S,S)-Me-BPE?

The CAS number is 136779-26-5, and its empirical formula is C14H28P2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product at a minimum purity of 95%. We do not represent this product as USP, BP, or EP grade.

What are the primary hazards associated with this chemical?

This chemical is pyrophoric (H250) and ignites spontaneously in air. It should be handled under an inert atmosphere. Eye protection, gloves, and appropriate respiratory protection are mandatory.

How is this chemical shipped and exported?

This chemical is classified as pyrophoric and is shipped under UN 2845 (4.2) in compliance with international regulations for hazardous materials transport.