(−)-1,2-Bis[(2S,5S)-2,5-diethylphospholano]ethane

CAS 136779-27-65S)-2Chemical Synthesis

(−)-1,2-Bis[(2S,5S)-2,5-diethylphospholano]ethane (CAS: 136779-27-6) is a chiral diphosphine ligand with the molecular formula C18H36P2 and a molecular weight of 314.43 g/mol. This compound is primarily utilised in asymmetric synthesis, functioning as a highly effective privileged ligand in various catalytic applications. Its specific stereochemistry makes it valuable for achieving high enantioselectivity in chemical transformations. Tech Serve Solutions offers this chemical for research and synthesis purposes.

IUPAC: (S,S)-Et-BPE
Synonyms: 5-diethylphospholano]ethane,136779-27-6

Email us

(−)-1,2-Bis[(2S,5S)-2,5-diethylphospholano]ethane (5S)-2) — chemical structure, CAS 136779-27-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentsDuPhos/BPE

01 /Applications

Asymmetric Catalysis

This diphosphine ligand is employed in transition metal catalysis to facilitate enantioselective reactions. It is particularly noted for its efficacy in asymmetric hydrogenation and other stereoselective transformations, enabling the synthesis of chiral molecules.

Chiral Ligand Synthesis

As a component of privileged ligand systems like DuPhos and BPE, it contributes to the development of advanced catalytic processes. These ligands are crucial for achieving high yields and selectivities in complex organic synthesis.

Pharmaceutical Intermediates

The ability to control stereochemistry is vital in pharmaceutical development. This ligand can be instrumental in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and their precursors.

02 /Properties

Molecular weight	314.43
Empirical formula	C18H36P2
Boiling point	104-106 °C/0.05 mmHg
Refractive index	n20/D 1.5243
Application	DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

Danger

Hazard statements

H250Catches fire spontaneously if exposed to air

Precautionary statements

P222Do not allow contact with air
P231Handle under inert gas
P422

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Transport (UN / ADR)	UN 2845 4.2
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F
Risk statements (R)	17
Safety statements (S)	6

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136779-27-6

MDL number

MFCD01073769

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (S,S)-Et-BPE used for?

(S,S)-Et-BPE is a chiral diphosphine ligand used in asymmetric catalysis, particularly for enantioselective transformations in chemical synthesis.

What are the CAS number and formula for (S,S)-Et-BPE?

The CAS number is 136779-27-6, and the empirical formula (Hill notation) is C18H36P2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product for research and laboratory use. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this chemical as meeting USP, BP, or EP pharmacopoeial standards.

How should (S,S)-Et-BPE be handled?

This compound is pyrophoric (H250) and requires careful handling under an inert atmosphere. Always use appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, as indicated by the safety data sheet.

How is this chemical shipped?

Due to its pyrophoric nature, this chemical is shipped as UN 2845, Hazard Class 4.2, under specific regulations for self-heating substances. TSS ensures compliant and secure export procedures.