(R)-(−)-3-Hydroxytetrahydrofuran
(R)-(−)-3-Hydroxytetrahydrofuran (CAS 86087-24-3, C4H8O2) is a chiral building block with a molecular weight of 88.11 g/mol. This heterocyclic compound is a valuable intermediate in asymmetric synthesis, particularly for creating complex organic molecules. Its specific stereochemistry makes it crucial in the development of pharmaceuticals and other fine chemicals where precise molecular architecture is essential.
Asymmetric Synthesis
(R)-(−)-3-Hydroxytetrahydrofuran serves as a key chiral synthon in asymmetric synthesis. Its defined stereocenter allows for the stereoselective construction of complex molecules, essential in the pharmaceutical and fine chemical industries.
Pharmaceutical Intermediates
This compound is used as a building block in the synthesis of various active pharmaceutical ingredients (APIs). It is particularly noted for its role in the development of HIV protease inhibitors, contributing to the precise stereochemical requirements of these drugs.
Research and Development
As a versatile heterocyclic building block, it is employed in academic and industrial research labs for exploring novel synthetic pathways and developing new chemical entities. Its reactivity and chirality make it a valuable tool for organic chemists.
| Molecular weight | 88.11 |
|---|---|
| Empirical formula | C4H8O2 |
| Assay | 98% |
| Boiling point | 181 °C(lit.) |
| Density | 1.097 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.45(lit.) |
| Optical activity | [α]20/D −18°, c = 2.4 in methanol |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 82 °C / 179.6 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-3-Hydroxytetrahydrofuran used for?
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(R)-(−)-3-Hydroxytetrahydrofuran is primarily used in asymmetric synthesis and as a building block for pharmaceuticals, notably for HIV protease inhibitors. It is also utilized in chemical synthesis and research laboratories.
What are the CAS number and formula for (R)-(−)-3-Hydroxytetrahydrofuran?
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The CAS number is 86087-24-3 and the empirical formula is C4H8O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-3-Hydroxytetrahydrofuran with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should (R)-(−)-3-Hydroxytetrahydrofuran be handled?
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Warning: This product causes skin irritation, serious eye irritation, and respiratory irritation (H315, H319, H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure good ventilation.
How is (R)-(−)-3-Hydroxytetrahydrofuran packed and shipped?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals. Please contact us for specific packaging and shipping details relevant to your location and order requirements.
How can I request a sample or quote for (R)-(−)-3-Hydroxytetrahydrofuran?
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To request a sample or a quote for (R)-(−)-3-Hydroxytetrahydrofuran, please contact our sales team through the website or by phone.
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