tBuMePhos
tBuMePhos (CAS: 255837-19-5, C21H29P) is a phosphine ligand with a molecular weight of 312.43 g/mol. As a key Buchwald ligand, it is predominantly utilised in palladium-catalysed cross-coupling reactions. Its specific application includes the monoarylation of substrates such as malonate esters, 1,3-diketones, and isolated nitroalkanes, facilitating complex organic synthesis and pharmaceutical intermediate production.
- IUPAC
- 2-Di-tert-butylphosphino-2′-methylbiphenyl,t-Butyl MePhos
- Synonyms
- 2-Di-tert-butylphosphino-2′-methylbiphenylt-Butyl MePhos
Palladium-Catalysed Arylations
tBuMePhos serves as an efficient ligand in palladium-catalysed arylations. It is particularly effective for the monoarylation of malonate esters, 1,3-diketones, and nitroalkanes, enabling precise C-C bond formation.
Buchwald-Hartwig Cross-Coupling
This phosphine ligand is integral to Buchwald-Hartwig amination and related cross-coupling reactions. It facilitates the formation of C-N, C-O, and C-S bonds under mild conditions.
Catalysis and Organic Synthesis
Utilised in various catalytic processes, tBuMePhos aids in constructing complex molecular architectures. Its application spans research and development in fine chemicals and pharmaceutical synthesis.
| Molecular weight | 312.43 |
|---|---|
| Empirical formula | C21H29P |
| Assay | 97% |
| Application | A ligand for the palladium-catalyzed monoarylation of malonate esters, 1,3-diketones and isolated nitroalkanes. |
| Melting point | 90-95 °C |
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionHeck ReactionReductions |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tBuMePhos used for?
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tBuMePhos is used as a ligand in palladium-catalyzed reactions, including the monoarylation of malonate esters, 1,3-diketones, and nitroalkanes, and is important in Buchwald-Hartwig cross-coupling reactions.
What are the CAS number and chemical formula for tBuMePhos?
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The CAS number is 255837-19-5 and the chemical formula is C21H29P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tBuMePhos with an assay of 97%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
What are the safety considerations when handling tBuMePhos?
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tBuMePhos is classified under WGK 2 (Germany), indicating it is hazardous to water. Standard laboratory safety precautions, including appropriate personal protective equipment and handling in a well-ventilated area, should be followed.
How is tBuMePhos shipped and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, ensuring compliant packaging and shipping for international destinations.
How can I request a sample or quote for tBuMePhos?
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To request a sample or a quotation for tBuMePhos, please contact our sales department through the website or by phone.
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