SPhos
SPhos (CAS 657408-07-6, C26H35O2P) is a highly universal phosphine ligand, essential in modern synthetic chemistry. With a molecular weight of 410.53, it is widely employed as a catalyst component in various cross-coupling reactions. Its efficacy in forming challenging carbon-carbon and carbon-heteroatom bonds makes it invaluable for synthesizing complex organic molecules, particularly in pharmaceutical and materials science research.
- IUPAC
- 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl impregnated tablets,S-Phos impregnated tablets,ChemDose™, S-Phos tablets
- Synonyms
- 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl impregnated tablets,S-Phos impregnated tablets,ChemDose™, S-Phos tablets
Suzuki-Miyaura Coupling
SPhos is a premier ligand for Suzuki-Miyaura cross-coupling reactions. It is particularly effective for coupling aryl chlorides, sterically hindered biaryls, and heterobiaryls, enabling the synthesis of complex molecular architectures.
Buchwald-Hartwig Amination
This ligand is a crucial component in Buchwald-Hartwig amination reactions, facilitating the formation of carbon-nitrogen bonds. It is highly effective for the coupling of aryl halides and pseudohalides with primary and secondary amines.
General Cross-Coupling
Beyond specific named reactions, SPhos serves as a versatile ligand for a range of palladium-catalysed cross-coupling processes. Its ability to activate challenging substrates broadens its applicability in complex molecule synthesis.
Catalysis Development
SPhos is an important tool for researchers developing new catalytic systems. Its well-defined properties and broad reactivity profile make it a benchmark ligand for optimising reaction conditions and exploring novel transformations.
| Molecular weight | 410.53 |
|---|---|
| Empirical formula | C26H35O2P |
| Assay | 97% |
| Application | Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls. |
| Melting point | 164-166 °C(lit.) |
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Matrix | Magnesium aluminometasilicate base material |
|---|---|
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionHeck ReactionKumada CouplingNegishi CouplingSuzuki-Miyaura Coupling |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SPhos used for?
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SPhos is a highly effective ligand for palladium-catalysed cross-coupling reactions, including Suzuki-Miyaura coupling and Buchwald-Hartwig amination. It is particularly useful for coupling aryl chlorides and sterically hindered substrates.
What is the CAS number and molecular formula for SPhos?
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The CAS number for SPhos is 657408-07-6, and its molecular formula is C26H35O2P.
What grade and purity does Tech Serve Solutions supply for SPhos?
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Tech Serve Solutions supplies SPhos with an assay of 97%. This product is intended for research and development purposes and is not represented as USP, EP, or BP grade.
What are the safety and handling requirements for SPhos?
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Handling SPhos requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Please refer to the Safety Data Sheet for detailed handling information. It carries GHS hazard classification WGK Germany 3.
How is SPhos typically packed and shipped?
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SPhos is supplied impregnated on a magnesium aluminometasilicate base material in tablet form for ease of handling and precise dosing. It is available in development quantities for research. TSS exports globally.
How can I request a quote or sample of SPhos?
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To request a quote or a sample of SPhos, please contact our sales team through the TSS website or by phone. Our representatives will assist you with your inquiry.
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