N-Boc-2-piperidineethanol
N-Boc-2-piperidineethanol (CAS: 118811-03-3), a crucial organic compound with the formula C12H23NO3 and a molecular weight of 229.32 g/mol, serves as a valuable building block in chemical synthesis. This tert-butyl protected piperidine derivative facilitates the construction of complex molecules. It is particularly employed as a reactant in the development of pharmaceutical intermediates, including receptor antagonists and enzyme inhibitors, highlighting its significance in medicinal chemistry research.
- IUPAC
- 1-tert-Butoxycarbonyl-2-piperidineethanol,2-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester,N-Boc-2-(2-hydroxymethyl)piperidine
- Synonyms
- 1-tert-Butoxycarbonyl-2-piperidineethanol2-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl esterN-Boc-2-(2-hydroxymethyl)piperidine
Synthesis of Vasopressin1b Receptor Antagonists
N-Boc-2-piperidineethanol is utilised as a key reactant in the synthesis of vasopressin1b receptor antagonists, important compounds in pharmacological research and development.
Development of CXCR4 Antagonists
This compound serves as a reactant in the synthesis of CXCR4 antagonists, which are being investigated for their potential as anti-HIV agents.
Preparation of Inducible Nitric Oxide Synthase Inhibitors
It functions as a reactant in the creation of coumarin-based inhibitors targeting inducible nitric oxide synthase (iNOS).
Synthesis of Selective Thrombin Inhibitors
N-Boc-2-piperidineethanol is employed as a reactant in synthetic routes leading to selective thrombin inhibitors, compounds with relevance in anticoagulation research.
N-Directed Hydroboration Reactions
The compound is used as a reactant in N-directed hydroboration reactions for the synthesis of various amino alcohols.
Enantioselective Synthesis of Sedamine and Allosedamine
It participates as a reactant in the enantioselective synthesis of natural products like sedamine and allosedamine.
| Molecular weight | 229.32 |
|---|---|
| Empirical formula | C12H23NO3 |
| Assay | 97% |
| Boiling point | 100-110 °C/0.3 mmHg |
| Density | 1.032 g/mL at 25 °C |
| Refractive index | n20/D 1.472 |
| Application | Reactant for synthesis of:• Vasopressin1b receptor antagonists1• CXCR4 antagonists as anti-HIV agents2• Coumarin-based inhibitors of inducible nitric oxide synthase3• Selective thrombin inhibitors4Reactant for: • N-directed hydroboration for synthesis of amino alcohols5• Enantioselective synthesis of sedamine and allosedamine6 |
Hazard statements
- H301Toxic if swallowed
- H319Causes serious eye irritation
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 2810 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-2-piperidineethanol used for?
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N-Boc-2-piperidineethanol (CAS: 118811-03-3) is used as a reactant in the synthesis of various pharmaceutical intermediates, including vasopressin1b receptor antagonists, CXCR4 antagonists (anti-HIV agents), coumarin-based iNOS inhibitors, and selective thrombin inhibitors. It is also used in N-directed hydroboration for amino alcohol synthesis and in the enantioselective synthesis of sedamine and allosedamine.
What are the CAS number and formula for N-Boc-2-piperidineethanol?
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The CAS number for N-Boc-2-piperidineethanol is 118811-03-3, and its empirical formula is C12H23NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-2-piperidineethanol with a purity of 97%. This product is suitable for research and synthesis; TSS does not represent it as USP, BP, or EP grade.
How should N-Boc-2-piperidineethanol be handled?
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N-Boc-2-piperidineethanol is classified as Danger, with hazards including H301 (Toxic if swallowed) and H400 (Very toxic to aquatic life). It requires appropriate personal protective equipment, including eyeshields, face shields, and gloves. Handling should occur in a well-ventilated area, and care must be taken to avoid environmental release. Refer to the safety data sheet for comprehensive handling instructions.
How is N-Boc-2-piperidineethanol packed, shipped, and exported?
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N-Boc-2-piperidineethanol is packed and shipped according to relevant regulations for hazardous materials, including UN 2810 (Toxic solid, organic, n.o.s.). As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide.
How can I request a sample or quote for N-Boc-2-piperidineethanol?
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To request a sample or a quote for N-Boc-2-piperidineethanol, please contact the Tech Serve Solutions sales team through our website or by phone. Please provide your contact details and the quantity required.
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