N-(6-((tert-Butyldimethylsilyloxy)methyl)-2-chloropyridin-3-yl)pivalamide
N-(6-((tert-Butyldimethylsilyloxy)methyl)-2-chloropyridin-3-yl)pivalamide (CAS 1142191-94-3; molecular formula C17H29ClN2O2Si; molar mass 356.96 g/mol) is a multifunctional pyridine building block. It combines a chloropyridine core, a tert-butyldimethylsilyl (TBS) protected hydroxymethyl group and a pivalamide directing group, giving distinct, orthogonally addressable sites for cross-coupling and functionalisation. Tech Serve Solutions supplies it as a research-grade intermediate for pharmaceutical and fine-chemical synthesis.
- Synonyms
- N-(6-((tert-Butyldimethylsilyloxy)methyl)-2-chloropyridin-3-yl)pivalamideN-[6-[[(tert-butyldimethylsilyl)oxy]methyl]-2-chloropyridin-3-yl]pivalamideN-{6-[(tert-butyldimethylsilyloxy)methyl]-2-chloropyridin-3-yl}-2,2-dimethylpropanamideCAS 1142191-94-3
Halogenated heterocyclic building block
The 2-chloropyridine moiety serves as a handle for palladium- or copper-catalysed cross-coupling and nucleophilic aromatic substitution, enabling further elaboration of the pyridine ring during multistep synthesis.
Pharmaceutical intermediate
Its combination of an aminopyridine scaffold and protected functionality makes it useful in the preparation of more complex drug candidates and pharmaceutical intermediates. Specific downstream uses depend on the customer's synthetic route.
TBS-protected hydroxymethyl handle
The tert-butyldimethylsilyl ether masks a primary hydroxymethyl group, allowing selective reactions elsewhere on the molecule; the silyl protecting group can later be removed under standard fluoride or acidic conditions to reveal the alcohol.
Pivalamide directing and protecting group
The bulky pivaloyl amide protects the ring amine and can act as a directing group in metalation and C-H functionalisation chemistry, supporting regioselective transformations of the pyridine core.
Research and discovery chemistry
As an organosilicon, organometallic-compatible reagent, it is suited to medicinal-chemistry and process-development laboratories that require well-defined, multifunctional pyridine intermediates for structure-activity studies.
| Molecular weight | 356.96 |
|---|---|
| Empirical formula | C17H29ClN2O2Si |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(6-((tert-Butyldimethylsilyloxy)methyl)-2-chloropyridin-3-yl)pivalamide used for?
+
It is used as a multifunctional pyridine building block in organic and pharmaceutical synthesis. The chloropyridine site supports cross-coupling and substitution, the TBS ether protects a hydroxymethyl group, and the pivalamide protects the ring amine and can direct metalation, making the compound a versatile intermediate for multistep routes.
What is the CAS number and molecular formula of N-(6-((tert-Butyldimethylsilyloxy)methyl)-2-chloropyridin-3-yl)pivalamide?
+
Its CAS number is 1142191-94-3 and its molecular formula is C17H29ClN2O2Si (Hill notation), corresponding to a molecular weight of 356.96 g/mol.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound as a research- and technical-grade synthetic intermediate. We do not represent it as USP, BP or EP pharmacopoeial grade. Current assay, lot-specific purity and a certificate of analysis are provided on request and with each shipment.
How should this compound be handled and stored safely?
+
Handle it as a laboratory research chemical: use appropriate personal protective equipment, work with adequate ventilation, and avoid contact with skin, eyes and inhalation of dust. Store in a tightly closed container in a cool, dry place away from moisture and incompatible materials. Always consult the current Safety Data Sheet, which accompanies every order, before use.
How is N-(6-((tert-Butyldimethylsilyloxy)methyl)-2-chloropyridin-3-yl)pivalamide packed, shipped and exported?
+
It is packed in appropriately sealed containers sized to the order, with tamper-evident, moisture-protective packaging and full labelling. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international documentation and shipping; packaging and transport are handled in line with the applicable regulations and the Safety Data Sheet.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with the product name or CAS number 1142191-94-3 and your required quantity. Our team will confirm availability, current specifications, lead time and export terms, and can provide a sample or a formal quotation for your project.
▶ Related products
4-Amino-2-chloropyridine
C5H5ClN2
Heterocyclic Building Blocks
4-Ethynyl-1-methyl-1H-pyrazole
C6H6N2
Heterocyclic Building Blocks
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
C12H11NO3
Heterocyclic Building Blocks
4-isocyanatopyridine
C6H4N2O
Heterocyclic Building Blocks
5-Chloro-2,8-dimethylquinoline
Heterocyclic Building Blocks
5-Chloro-2-methylene-1,3,3-trimethylindoline
Heterocyclic Building Blocks
5-Chloro-2-thiophenecarbonitrile
Heterocyclic Building Blocks
5-ethynyl-1H-pyrazole
C5H4N2
Heterocyclic Building Blocks
