N-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide
N-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide (CAS 113975-32-9; C10H13IN2O; molar mass 304.13 g/mol) is a halogenated pyridine building block in which a 3-aminopyridine is protected as its pivalamide and the adjacent 4-position bears an iodine. It is used in pharmaceutical and fine-chemical synthesis, where the pivaloyl group directs ortho-metalation and the aryl iodide serves as a versatile handle for palladium-catalysed cross-coupling. Tech Serve Solutions supplies it to research and manufacturing customers worldwide.
- Synonyms
- N-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamideN-(4-Iodopyridin-3-yl)pivalamide2,2-Dimethyl-N-(4-iodopyridin-3-yl)propanamideN-(4-Iodo-3-pyridinyl)-2,2-dimethylpropanamideN-(4-Iodopyridin-3-yl)-2,2-dimethylpropanamide
Pharmaceutical and fine-chemical building block
Serves as a functionalised pyridine intermediate in the synthesis of pharmaceutical candidates, agrochemicals and other fine chemicals. The combination of a protected amino group and a reactive aryl iodide makes it a convenient point of elaboration.
Cross-coupling substrate
The carbon-iodine bond is a reactive site for palladium- and copper-catalysed reactions such as Suzuki, Heck, Sonogashira, Negishi and related couplings, allowing carbon-carbon and carbon-heteroatom bonds to be formed at the pyridine 4-position.
Directed ortho-metalation
The 2,2-dimethylpropionamide (pivalamide) acts as a directing and protecting group, supporting regioselective directed ortho-metalation chemistry and the controlled introduction of further substituents on the pyridine ring.
Halogenated heterocyclic scaffold
As a member of the halogenated pyridine and heterocyclic building-block family, it is used to assemble more complex nitrogen-containing ring systems and substituted pyridine scaffolds in medicinal-chemistry programmes.
Research and discovery chemistry
Used at laboratory and pilot scale in discovery and process-research settings where a pre-functionalised aminopyridine with an orthogonal halide handle is required.
| Molecular weight | 304.13 |
|---|---|
| Empirical formula | C10H13IN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide used for?
+
It is used as a synthetic building block in pharmaceutical and fine-chemical synthesis. The aryl iodide provides a handle for palladium-catalysed cross-coupling, while the pivalamide group protects the 3-amino position and directs ortho-metalation, making the molecule useful for building substituted pyridine scaffolds.
What is the CAS number and molecular formula of N-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide?
+
Its CAS number is 113975-32-9 and its empirical formula is C10H13IN2O (Hill notation), corresponding to a molecular weight of 304.13 g/mol.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound as a research and laboratory-reagent grade building block. We do not represent it as USP, BP or EP pharmacopoeia grade. A current Certificate of Analysis stating the actual assay for the available lot is provided on request, and specifications can be confirmed at the time of enquiry.
What are the safety and handling requirements?
+
No supplier GHS classification is provided in our current dataset, so the product should be handled as a research chemical of undetermined hazard. Use general good laboratory practice: work in a fume hood, wear suitable gloves, eye protection and a lab coat, avoid dust, skin and eye contact, and keep containers tightly closed in a cool, dry, well-ventilated area. Always review the Safety Data Sheet supplied with the consignment before use.
How is N-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
+
It is packed in appropriately labelled containers sized to the order, from gram quantities for research to larger volumes for scale-up. As an exporter since 1998, Tech Serve Solutions arranges compliant documentation, labelling and international freight, with packaging and transport configured to the destination and to the relevant regulations.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, intended destination and any specification or documentation needs. We will confirm availability, lead time, current assay and packaging, and can arrange a sample or a formal quotation.
▶ Related products
4-Amino-2-chloropyridine
C5H5ClN2
Heterocyclic Building Blocks
4-Ethynyl-1-methyl-1H-pyrazole
C6H6N2
Heterocyclic Building Blocks
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
C12H11NO3
Heterocyclic Building Blocks
4-isocyanatopyridine
C6H4N2O
Heterocyclic Building Blocks
5-Chloro-2,8-dimethylquinoline
Heterocyclic Building Blocks
5-Chloro-2-methylene-1,3,3-trimethylindoline
Heterocyclic Building Blocks
5-Chloro-2-thiophenecarbonitrile
Heterocyclic Building Blocks
5-ethynyl-1H-pyrazole
C5H4N2
Heterocyclic Building Blocks
