Methyl 6-methoxy-2-indolecarboxylate
Methyl 6-methoxy-2-indolecarboxylate (CAS 98081-83-5; C11H11NO3; molar mass 205.21 g/mol) is a substituted indole building block supplied by Tech Serve Solutions as a research-grade solid at 99% assay. The methyl ester and 6-methoxy substituent make it a versatile heterocyclic intermediate, widely used in medicinal chemistry and chemical synthesis to construct functionalised indole, indolone and latonduine-type scaffolds. Tech Serve Solutions supplies and exports it worldwide for laboratory and process research applications.
- IUPAC
- 2-Methoxycarbonyl-6-methoxyindole,6-Methoxyindole-2-carboxylic acid methyl ester
- Synonyms
- Methyl 6-methoxy-2-indolecarboxylate2-Methoxycarbonyl-6-methoxyindole6-Methoxyindole-2-carboxylic acid methyl esterMethyl 6-methoxy-1H-indole-2-carboxylate6-Methoxy-1H-indole-2-carboxylic acid methyl ester
Heterocyclic building block
Serves as a 2-substituted indole scaffold for elaboration into more complex heterocyclic systems. The reactive methyl ester and 6-methoxy group give defined handles for functionalisation in multistep synthesis.
Medicinal chemistry intermediate
Used as a reactant in the preparation of indole-based candidates studied for biological activity, including reported antiproliferative agents and dual peroxisome proliferator-activated receptor (PPAR) agonist analogues. Suited to discovery-scale and process research.
Latonduine and indolone scaffold synthesis
Applied as a precursor to latonduine derivatives via intramolecular Heck reactions and to indole-indolone scaffolds through [3+2] annulation of arynes, supporting work on potential anticancer agents.
Tubulin and inhibitor research
Employed in routes to arylthioindoles investigated as inhibitors of tubulin polymerisation, and in related indole derivatives prepared by Ugi condensation and other annulation strategies.
Reference and laboratory reagent
Its defined identity (CAS 98081-83-5, MDL MFCD00134301) and 99% assay make it suitable as a reagent and reference material for method development and analytical work.
| Molecular weight | 205.21 |
|---|---|
| Empirical formula | C11H11NO3 |
| Assay | 99% |
| Application | Reactant for preparation of: • Benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists1• Potent antiproliferative agent against human leukemia K562 cells2• Indole-indolone scaffold via [3+2] annulation of arynes3• Latonduine derivatives via intramolecular Heck reaction as possible anticancer agents4• Arylthioindoles as potent inhibitors of tubulin polymerization5• Heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine via Ugi condensation6• Indole fatty alcohols (IFAs) as promoters of differentiation of neural stem cell derived neurospheres into neurons. Potential application for treatment of neurodegenerative diseases7• Light-dependent tumor necrosis factor-α antagonists8• 2-substituted indole me |
| Melting point | 117-119 °C(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 6-methoxy-2-indolecarboxylate used for?
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It is used mainly as a heterocyclic building block and intermediate in chemical synthesis and medicinal chemistry. Documented uses include preparing latonduine derivatives, indole-indolone scaffolds, arylthioindole tubulin-polymerisation inhibitors and PPAR agonist analogues. Tech Serve Solutions supplies it for laboratory and process research.
What is the CAS number and molecular formula of Methyl 6-methoxy-2-indolecarboxylate?
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Its CAS number is 98081-83-5 and its molecular formula is C11H11NO3 (Hill notation), with a molecular weight of 205.21 g/mol. The MDL number is MFCD00134301 and the PubChem Substance ID is 24862540. It is a solid with a melting point of 117-119 °C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 6-methoxy-2-indolecarboxylate at 99% assay as a research and technical grade material for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and specifications can be confirmed at the time of enquiry.
What are the safety and handling requirements?
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No GHS pictograms, signal word or hazard statements are provided in our current data for this compound, so it is not classified here as a specific physical or health hazard; however, it is assigned Water Hazard Class WGK 3 (Germany), indicating it is severely hazardous to water and must not be released to the environment. Handle as a research chemical using good laboratory practice, appropriate personal protective equipment and adequate ventilation. Always consult the Safety Data Sheet before use.
How is Methyl 6-methoxy-2-indolecarboxylate packed, shipped and exported?
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It is supplied as a solid in tightly closed, suitably labelled containers, with pack sizes from gram quantities upwards to meet laboratory and bulk research needs. Tech Serve Solutions ships and exports worldwide, with documentation and packaging arranged to suit the destination and the agreed quantity.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, intended purity and delivery destination, and our team will provide a quotation, available specifications and lead time. Sample availability can be confirmed on request.
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