Di-tert-butylmethylphosphine
Di-tert-butylmethylphosphine (CAS: 6002-40-0), with the chemical formula [(CH3)3C]2PCH3 and a molecular weight of 160.24 g/mol, is a bulky phosphine ligand. It is primarily employed in conjunction with various palladium complexes for catalytic applications, particularly in cross-coupling reactions. This compound is supplied by TSS with an assay of 97%.
- IUPAC
- (t-Bu)2PMe,Bis(tert-butyl)methylphosphine
![Di-tert-butylmethylphosphine ([(CH3)3C]2PCH3) — chemical structure, CAS 6002-40-0; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F6002-40-0.png&w=3840&q=75)
Cross-Coupling Catalysis
Di-tert-butylmethylphosphine serves as a crucial ligand in palladium-catalysed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig, and Heck couplings. Its bulky nature can influence reaction selectivity and efficiency.
Homogeneous Catalysis
This phosphine is utilised in homogeneous catalytic systems where its steric and electronic properties can modify the activity of metal centres. It is a valuable tool in organic synthesis for the formation of carbon-carbon and carbon-heteroatom bonds.
Ligand in Organometallic Chemistry
As a P-donor ligand, Di-tert-butylmethylphosphine can coordinate to various transition metals, forming complexes relevant to catalysis and inorganic chemistry research. Its strong sigma-donating ability and steric bulk are key features.
| Molecular weight | 160.24 |
|---|---|
| Linear formula | [(CH3)3C]2PCH3 |
| Assay | 97% |
| Boiling point | 58 °C/12 mmHg(lit.) |
| Density | 0.824 g/mL at 25 °C(lit.) |
| Application | Bulky phosphine used with various palladium complexes in cross-coupling catalysis.1 |
Hazard statements
- H250Catches fire spontaneously if exposed to air
- H314Causes severe skin burns and eye damage
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2845 4.2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 17-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butylmethylphosphine used for?
+
Di-tert-butylmethylphosphine is primarily used as a bulky phosphine ligand in palladium-catalysed cross-coupling reactions and other homogeneous catalytic processes.
What is the CAS number and chemical formula for Di-tert-butylmethylphosphine?
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The CAS number is 6002-40-0 and the chemical formula is [(CH3)3C]2PCH3.
What grade and purity does Tech Serve Solutions supply for Di-tert-butylmethylphosphine?
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Tech Serve Solutions supplies Di-tert-butylmethylphosphine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should Di-tert-butylmethylphosphine be handled and stored?
+
Di-tert-butylmethylphosphine is highly flammable and pyrophoric, reacting with air (H250) and causing severe skin burns and eye damage (H314). It must be handled under an inert atmosphere (e.g., nitrogen or argon) using appropriate personal protective equipment, including gloves, goggles, and a full-face respirator. Store in a cool, well-ventilated place away from ignition sources.
Is Di-tert-butylmethylphosphine exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Di-tert-butylmethylphosphine.
How can I request a quote or sample for Di-tert-butylmethylphosphine?
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To request a quote or sample, please contact our sales team through the TSS website or by phone, providing the product name and CAS number (6002-40-0).
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