Z-Leu-OH

CAS 2018-66-8(CH3)2CHCH2CH(NHCOOCH2C6H5)COOHChemical Synthesis

N-(Benzyloxycarbonyl)-L-leucine (CAS 2018-66-8) is a protected amino acid derivative with a molecular weight of 265.30 g/mol. Utilised in chemical synthesis and peptide chemistry, it serves as a key reactant in the preparation of various complex organic molecules. This compound is specifically employed in the development of potential antitumor agents and cyclopropyl peptidomimetics, contributing to advancements in medicinal chemistry and drug discovery.

IUPAC: N-(Benzyloxycarbonyl)-L-leucine,N-(Benzyloxycarbonyl)leucine,N-(Carbobenzoxy)leucine,N-(Phenylmethoxy)carbonyl-L-leucine,N-Carbobenzoxy-L-leucine,N-Carbobenzyloxy-L-leucine,N-Carboxy-L-leucine N-benzyl ester,N-Cbz-L-leucine,Benzyloxycarbonyl-L-leucine,Benzyloxycarbonylleucine,Carbobenzoxyleucine,L-N-(Benzyloxycarbonyl)leucine,L-(Carbobenzyloxy)leucine,NSC 60039,Z-L-Leucine
Synonyms: N-(Benzyloxycarbonyl)-L-leucineN-(Carbobenzoxy)leucineN-Carbobenzyloxy-L-leucineN-Cbz-L-leucineBenzyloxycarbonyl-L-leucineZ-L-Leucine

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Z-Leu-OH ((CH3)2CHCH2CH(NHCOOCH2C6H5)COOH) — chemical structure, CAS 2018-66-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisLeucinePeptide Chemistry

01 /Applications

Peptide-Based Antitumor Agents

N-(Benzyloxycarbonyl)-L-leucine is a crucial reactant in the peptide-based preparation of potential antitumor agents, facilitating the synthesis of novel therapeutic candidates.

Cyclopropyl Peptidomimetics Synthesis

This compound is employed in the preparation of cyclopropyl peptidomimetics, contributing to the development of drug-like molecules with modified structures.

General Peptide Synthesis

As a protected amino acid derivative, it finds broad application in standard peptide synthesis methodologies for constructing peptide chains.

02 /Properties

Molecular weight	265.30
Linear formula	(CH3)2CHCH2CH(NHCOOCH2C6H5)COOH
Assay	≥96.0% (T)
Density	1 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.512(lit.)
Optical activity	[α]20/D −16±1°, c = 2% in ethanol
Application	Reactant for:• Peptide-based preparation of potential antitumor agents1• Preparation of cyclopropyl peptidomimetics2• Peptide synthesis3

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Warning

Hazard statements

H226Flammable liquid and vapour
H351Suspected of causing cancer
H361D

Flash point	29 °C / 84.2 °F
Transport (UN / ADR)	UN 1993C 3 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	63-10-40-67
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2018-66-8

MDL number

MFCD00026494

Beilstein registry

1253861

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is N-(Benzyloxycarbonyl)-L-leucine used for?

N-(Benzyloxycarbonyl)-L-leucine is used as a reactant in the preparation of potential antitumor agents, cyclopropyl peptidomimetics, and in general peptide synthesis.

What are the CAS number and formula for N-(Benzyloxycarbonyl)-L-leucine?

The CAS number is 2018-66-8, and its linear formula is (CH₃)₂CHCH₂CH(NHCOOCH₂C₆H₅)COOH.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies N-(Benzyloxycarbonyl)-L-leucine with an assay of ≥96.0% (T). We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.

How should N-(Benzyloxycarbonyl)-L-leucine be handled safely?

N-(Benzyloxycarbonyl)-L-leucine is a flammable liquid and vapour (H226). It may also cause genetic defects and damage fertility or the unborn child (H351, H361d). Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources.

Is N-(Benzyloxycarbonyl)-L-leucine suitable for export?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including N-(Benzyloxycarbonyl)-L-leucine, adhering to all necessary shipping regulations.