XPhos
XPhos (CAS 564483-18-7), with the chemical formula C33H49P and a molecular weight of 476.72 g/mol, is a highly effective phosphine ligand. It is specifically designed to enhance the scope and efficiency of palladium-catalyzed cross-coupling reactions, particularly amination and amidation processes involving aryl halides and sulfonates. Available from Tech Serve Solutions, XPhos is a valuable reagent for modern synthetic organic chemistry.
- IUPAC
- 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl impregnated tablets,ChemDose™, X-Phos impregnated tablets
Palladium-Catalyzed Amination
XPhos serves as a crucial ligand in palladium-catalyzed amination reactions. It facilitates the formation of C-N bonds with a broader range of substrates, including aryl halides and sulfonates, enabling more versatile synthetic routes.
Buchwald-Hartwig Cross-Coupling
This ligand is integral to the Buchwald-Hartwig cross-coupling reaction, a powerful method for forming carbon-nitrogen bonds. XPhos improves reaction rates and substrate scope in these transformations.
Cross-Coupling Reactions
XPhos is broadly applicable to various palladium-catalyzed cross-coupling reactions, including C-C bond formation, Heck, Suzuki-Miyaura, and Sonogashira couplings, enhancing catalytic efficiency.
| Molecular weight | 476.72 |
|---|---|
| Empirical formula | C33H49P |
| Assay | 97% |
| Application | Ligand for increased scope of Pd-catalyzed amination and amidation via arene sulfonates, aryl halides.1 |
| Melting point | 187-190 °C(lit.) |
Hazard statements
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Greener Alternative Product Characteristics | Catalysis |
|---|---|
| Matrix | Magnesium aluminometasilicate base material |
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionC-C Bond FormationHeck ReactionHiyama CouplingNegishi CouplingSonogashira CouplingStille CouplingSuzuki-Miyaura Coupling |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is XPhos primarily used for?
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XPhos is primarily used as a ligand to enhance the scope and efficiency of palladium-catalyzed cross-coupling reactions, such as amination, amidation, and C-C bond formation.
What is the CAS number and chemical formula for XPhos?
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The CAS number for XPhos is 564483-18-7, and its chemical formula is C33H49P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies XPhos with an assay of 97%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling requirements for XPhos?
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XPhos carries the hazard statement H413, indicating it may cause long lasting harmful effects to aquatic life. Appropriate personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Handle in accordance with safety data sheets.
How is XPhos shipped and exported by TSS?
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Tech Serve Solutions, as a specialist global supplier and exporter of fine chemicals, handles the shipping and export of XPhos in compliance with all relevant regulations.
How can I request a sample or quote for XPhos?
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To request a sample or obtain a quote for XPhos, please contact the Tech Serve Solutions sales team through our official website or designated contact channels.
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