Tropisetron monohydrochloride
Tropisetron monohydrochloride (CAS 105826-92-4), a potent serotonin 5-HT3 receptor antagonist, presents as a solid with the empirical formula C17H20N2O2 · HCl and a molecular weight of 320.81. It is widely recognised for its role in chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). This compound serves as a valuable reference standard in analytical chemistry for drug quantification.
- IUPAC
- 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride,3-Tropanylindole-3-carboxylate monohydrochloride,ICS-205,930,Navoban
- Synonyms
- 3-Tropanylindole-3-carboxylate monohydrochlorideICS-205,930Navoban1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride
Analytical Reference Standard
Tropisetron monohydrochloride is employed as a standard for the quantitative determination of tropisetron in biological samples, such as human plasma, utilising High-Performance Liquid Chromatography (HPLC) with UV detection.
Research Chemical
As a selective 5-HT3 receptor antagonist, it is used in various research settings to investigate neurotransmission, cell signaling pathways, and the physiological roles of serotonin receptors in the central and peripheral nervous systems.
Drug Discovery and Development
This compound can be utilised in preclinical studies to explore the therapeutic potential of 5-HT3 receptor antagonists in conditions beyond nausea and vomiting, contributing to the development of novel therapeutics.
| Molecular weight | 320.81 |
|---|---|
| Empirical formula | C17H20N2O2 · HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | H2O: >10 mg/mL |
| Storage temperature | 2-8°C |
| Application | Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.1 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tropisetron monohydrochloride used for?
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Tropisetron monohydrochloride is primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy and radiotherapy, as well as postoperative nausea and vomiting. It also serves as an analytical reference standard in research and drug quantification.
What is the CAS number and chemical formula for Tropisetron monohydrochloride?
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The CAS number for Tropisetron monohydrochloride is 105826-92-4, and its chemical formula is C17H20N2O2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tropisetron monohydrochloride with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Tropisetron monohydrochloride be handled and stored?
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When handling Tropisetron monohydrochloride, it is essential to use personal protective equipment including eyeshields and gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Store the compound at 2-8°C to maintain its stability.
Is Tropisetron monohydrochloride a controlled substance?
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The provided data does not indicate that Tropisetron monohydrochloride is a controlled substance.
How can I request a quote or sample of Tropisetron monohydrochloride?
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To request a quote or sample of Tropisetron monohydrochloride, please contact our sales team through the website or by phone.
How is Tropisetron monohydrochloride packed, shipped, and exported?
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Tropisetron monohydrochloride is carefully packed to ensure stability during transit and is available for export globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
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