Tunicamycin from Streptomyces sp.

CAS 11089-65-9Biochemicals & Reagents

Tunicamycin from Streptomyces sp. (CAS: 11089-65-9) is a potent inhibitor of glycosylation, crucial for studying cellular processes. It specifically targets the enzyme UDP-glucose:dolichol phosphate glucosyltransferase, disrupting the first step in N-linked glycosylation. This makes it invaluable for research into protein modification, cell signalling, and viral replication mechanisms. Tech Serve Solutions supplies this high-quality reagent for advanced biochemical and cell biology applications.

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Tunicamycin from Streptomyces sp. — chemical structure, CAS 11089-65-9; Life Science, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Inhibition of N-linked Glycosylation

Tunicamycin is widely used as a research tool to inhibit the formation of N-linked glycoproteins. This allows researchers to investigate the role of glycosylation in protein folding, stability, and function.

Cell Signaling and Neuroscience Research

By blocking glycosylation, tunicamycin can modulate cell signalling pathways and is employed in neuroscience research to understand the effects of altered protein modification on neuronal function.

Antiviral and Antibacterial Studies

Tunicamycin has been utilised in studies examining viral entry and replication, as well as in investigations into antibacterial mechanisms, due to its interference with essential cellular processes.

Study of Membrane Protein Function

Its ability to inhibit glycosylation makes tunicamycin useful for characterising the function and trafficking of membrane proteins, particularly those dependent on proper glycosylation for their activity.

02 /Properties

Solubility	methanol: soluble4.9-5.1 mg/mL, clear to slightly hazy, colorless to yellowmethanol: soluble4.9-5.1 mg/mL95% ethanol: soluble1 mg/mL, clear to faintly hazyTHF: soluble dioxane: soluble DMF: soluble >10 mg/mLDMSO: soluble10 mg/mL, clearpyridine: >10 mg/mLacetone: insolubleaqueous base: insolublechloroform: insolubleethyl acetate: insoluble
Storage temperature	2-8°C
Application	Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells1. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells2.

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash thoroughly after handling
P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3462 6.1 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T+
Risk statements (R)	28
Safety statements (S)	28-37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

11089-65-9

MDL number

MFCD00065709

PubChem substance

24900473

Beilstein registry

6888090

05 /Additional specifications

Quality Level	PREMIUM

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tunicamycin used for?

Tunicamycin is used in research to inhibit N-linked glycosylation, study cell signalling, investigate viral replication, and examine membrane protein function. It is a valuable tool in biochemical and cell biology research.

What is the CAS number and formula for Tunicamycin?

The CAS number for Tunicamycin is 11089-65-9. The chemical formula is not provided in the product data.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tunicamycin at PREMIUM quality. The assay is not explicitly stated, and TSS does not represent it as USP, BP, or EP grade. It is intended for research and laboratory use.

How should Tunicamycin be handled safely?

Tunicamycin is acutely toxic if swallowed (H300) and requires careful handling. Use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Handle only in a well-ventilated area. Refer to the Safety Data Sheet for full handling instructions.

How is Tunicamycin packed, shipped, and exported?

Tunicamycin is typically stored at 2-8°C. Shipping and export details are handled according to international regulations for hazardous materials (UN 3462 6.1 / PGII). Please contact TSS for specific logistical information.

How can I request a sample or quote for Tunicamycin?

To request a sample or quote for Tunicamycin, please contact the Tech Serve Solutions sales team through our website or by phone. Provide the product name and CAS number (11089-65-9) for prompt service.