Tris(hydroxymethyl)phosphine

CAS 2767-80-8(HOCH2)3PCatalysis & Inorganic

Tris(hydroxymethyl)phosphine (CAS 2767-80-8), with the linear formula (HOCH₂ )₃P and a molecular weight of 124.08 g/mol, is a versatile phosphine compound. It is primarily recognised for its utility as a ligand in catalysis and as a building block in chemical synthesis. Its unique structure makes it valuable in various organometallic and coordination chemistry applications, contributing to the development of novel catalytic processes and complex molecular architectures.

IUPAC: Phosphinidynetrimethanol,Trimethylolphosphine,Tris(methanol)phosphine
Synonyms: PhosphinidynetrimethanolTrimethylolphosphineTris(methanol)phosphine

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Tris(hydroxymethyl)phosphine ((HOCH2)3P) — chemical structure, CAS 2767-80-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphine Ligands

01 /Applications

Ligand in Homogeneous Catalysis

Tris(hydroxymethyl)phosphine serves as a valuable ligand in homogeneous catalysis, forming complexes with transition metals. These complexes can catalyse a range of organic transformations, offering controlled reactivity and selectivity in synthetic pathways.

Reagent in Chemical Synthesis

This phosphine compound is employed as a reagent in various chemical synthesis procedures. Its nucleophilic nature and the presence of hydroxyl groups allow for diverse derivatisation and incorporation into more complex molecules.

Coordination Chemistry

It is used in coordination chemistry to study the formation and properties of metal-phosphine complexes. The hydroxymethyl groups can also participate in secondary interactions, influencing the supramolecular structure of coordination compounds.

02 /Properties

Molecular weight	124.08
Linear formula	(HOCH2)3P
Assay	90%
Boiling point	111-113 °C/2.5 mmHg(lit.)
Melting point	48-56 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P280Wear protective gloves, clothing and eye/face protection
P301IF SWALLOWED
P305IF IN EYES

Flash point	>110 °C / >230 °F
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25-37/38-41
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2767-80-8

MDL number

MFCD00055382

PubChem substance

24850698

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Tris(hydroxymethyl)phosphine used for?

Tris(hydroxymethyl)phosphine is primarily used as a ligand in catalysis and as a reagent in chemical synthesis, particularly in organometallic and coordination chemistry.

What are the CAS number and formula for Tris(hydroxymethyl)phosphine?

The CAS number for Tris(hydroxymethyl)phosphine is 2767-80-8, and its linear formula is (HOCH₂)₃P.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tris(hydroxymethyl)phosphine with an assay of 90%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeial grades.

How should Tris(hydroxymethyl)phosphine be handled safely?

Tris(hydroxymethyl)phosphine is a dangerous substance. It is toxic if swallowed, causes skin irritation, causes serious eye damage, and may cause respiratory irritation. Always handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling and emergency procedures.

Is Tris(hydroxymethyl)phosphine packed and shipped internationally by TSS?

Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including Tris(hydroxymethyl)phosphine, adhering to all necessary regulations for international shipment.

How can I request a quote or sample for Tris(hydroxymethyl)phosphine?

To request a quote or sample, please use the contact form on our website or email our sales department, specifying the product name and CAS number (2767-80-8).