Tris(dimethylamino)phosphine

CAS 1608-26-0P[N(CH3)2]3Catalysis & Inorganic

Tris(dimethylamino)phosphine (CAS 1608-26-0), with the chemical formula P[N(CH3)2]3, is a chemical compound featuring a central phosphorus atom bonded to three dimethylamino groups. This reagent, with a molecular weight of 163.20 g/mol, is primarily utilised in organic synthesis. Its notable applications include activating hydroxyl groups and facilitating dehydration reactions. It is also employed in combination with carbon tetrachloride for converting hydroxyls into chlorides.

IUPAC: HMPT,Hexamethylphosphorous triamide

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Tris(dimethylamino)phosphine (P[N(CH3)2]3) — chemical structure, CAS 1608-26-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphine Ligands

01 /Applications

Hydroxyl Group Activation

Tris(dimethylamino)phosphine is effective in activating hydroxyl groups, making them more susceptible to subsequent reactions. This activation is a key step in various synthetic pathways.

Dehydration Reactions

This phosphine compound serves as a reagent in dehydration reactions. It facilitates the removal of water molecules from organic substrates, leading to the formation of new functional groups or unsaturated systems.

Conversion to Chlorides

In combination with carbon tetrachloride, Tris(dimethylamino)phosphine enables the efficient conversion of hydroxyl groups into corresponding chloride functionalities. This reaction is valuable for introducing chlorine atoms into organic molecules.

02 /Properties

Molecular weight	163.20
Linear formula	P[N(CH3)2]3
Assay	85%
Boiling point	48-50 °C/12 mmHg(lit.)
Density	0.898 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.463(lit.)
Application	Reagent combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations.

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H226Flammable liquid and vapour
H340May cause genetic defects
H350May cause cancer

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	27 °C / 80.6 °F
Transport (UN / ADR)	UN 1993C 3 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	45-46-10
Safety statements (S)	53-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1608-26-0

MDL number

MFCD00008301

PubChem substance

24864511

Beilstein registry

906778

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Tris(dimethylamino)phosphine used for?

Tris(dimethylamino)phosphine is used as a reagent in organic synthesis for activating hydroxyl groups, facilitating dehydration reactions, and converting hydroxyl groups to chlorides when used with carbon tetrachloride.

What is the CAS number and chemical formula for Tris(dimethylamino)phosphine?

The CAS number for Tris(dimethylamino)phosphine is 1608-26-0, and its chemical formula is P[N(CH3)2]3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tris(dimethylamino)phosphine with an assay of 85%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.

What are the primary safety concerns when handling Tris(dimethylamino)phosphine?

Tris(dimethylamino)phosphine is a flammable liquid and vapour (H226). It is suspected of causing genetic defects (H340) and may cause cancer (H350). Handling requires strict adherence to safety protocols, including appropriate personal protective equipment such as eyeshields, face shields, gloves, and a suitable respirator.

How is Tris(dimethylamino)phosphine shipped and exported?

Tris(dimethylamino)phosphine is classified under UN 1993, Packing Group III, for transport. Tech Serve Solutions, as an experienced global supplier, handles the export of chemicals in compliance with international shipping regulations.

How can I request a sample or quote for Tris(dimethylamino)phosphine?

To request a sample or a quotation for Tris(dimethylamino)phosphine, please contact our sales department through the website or by calling our customer service line.