Trimethylsulfonium methyl sulfate
Trimethylsulfonium methyl sulfate (CAS 2181-44-4) is a chemical reagent with the linear formula (CH3)3S(OSO3CH3) and a molecular weight of 188.27. It is primarily recognised for its utility in organic synthesis, particularly as a methylenating agent for aldehydes and ketones, leading to the formation of epoxides. This compound serves as a valuable tool in chemical synthesis and for creating C-X bonds.

Epoxidation of Carbonyl Compounds
Trimethylsulfonium methyl sulfate is employed as a reagent for the methylenation of aldehydes and ketones. This process effectively converts carbonyl groups into epoxide rings, a crucial transformation in synthetic organic chemistry.
Alkyl Transfer Reagent
This compound functions as an effective alkyl transfer agent. It facilitates the transfer of alkyl groups in various synthetic pathways, contributing to the construction of complex organic molecules.
C-X Bond Formation
The reagent is useful in the formation of C-X bonds, specifically in non-halogen contexts. Its application aids in the controlled synthesis of target molecules where specific bond formations are required.
| Molecular weight | 188.27 |
|---|---|
| Linear formula | (CH3)3S(OSO3CH3) |
| Assay | 98% |
| Application | Useful reagent for the methylenation of aldehydes and ketones to form epoxides.1 |
| Melting point | 92-94 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethylsulfonium methyl sulfate used for?
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Trimethylsulfonium methyl sulfate is used as a reagent for the methylenation of aldehydes and ketones to form epoxides and as an alkyl transfer agent in chemical synthesis.
What is the CAS number and formula for Trimethylsulfonium methyl sulfate?
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The CAS number is 2181-44-4 and the linear formula is (CH3)3S(OSO3CH3).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethylsulfonium methyl sulfate with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product documentation.
How should Trimethylsulfonium methyl sulfate be handled safely?
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Trimethylsulfonium methyl sulfate is a Warning substance (GHS07) that may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). When handling, use a dust mask type N95 (US), wear eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
How is Trimethylsulfonium methyl sulfate packed, shipped, and exported?
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We ensure secure and compliant packaging for all our chemicals, suitable for domestic and international export. Specific packaging details can be provided upon request.
How can I request a sample or a quote for Trimethylsulfonium methyl sulfate?
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To request a sample or a quote, please contact our sales team through the website or by calling us directly. Please specify the quantity and delivery location.
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