Trimethyl(phenoxy)silane
Trimethyl(phenoxy)silane (CAS: 1529-17-5), with the molecular formula C6H5OSi(CH3)3 and a molecular weight of 166.29 g/mol, is a valuable organic building block. It serves as a protecting group for phenols and finds application in organic synthesis. Its primary role is in facilitating complex chemical transformations through its unique silyl ether functionality.
- IUPAC
- Phenoxy(trimethyl)silane,Phenyl trimethylsilyl ether
- Synonyms
- Phenoxy(trimethyl)silanePhenyl trimethylsilyl ether

Phenol Protection
Trimethyl(phenoxy)silane is commonly employed as a silylating agent to protect hydroxyl groups in phenols. This protection strategy is crucial in multi-step organic syntheses, preventing unwanted side reactions of the phenolic hydroxyl during other transformations.
Organic Synthesis Intermediate
As a versatile building block, this compound participates in various organic reactions. It contributes to the construction of more complex molecular architectures, making it a useful reagent in academic research and industrial chemical development.
Research and Development
Its specific chemical properties make it a reagent of interest in laboratories exploring novel synthetic routes and chemical methodologies. It aids in the development of new materials and pharmaceutical intermediates.
| Molecular weight | 166.29 |
|---|---|
| Linear formula | C6H5OSi(CH3)3 |
| Assay | 97% |
| Density | 0.92 g/mL at 25 °C(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 41 °C / 105.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethyl(phenoxy)silane used for?
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Trimethyl(phenoxy)silane is primarily used as a protecting group for phenols in organic synthesis and as a general building block for creating more complex molecules.
What are the CAS number and formula for Trimethyl(phenoxy)silane?
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The CAS number for Trimethyl(phenoxy)silane is 1529-17-5, and its linear formula is C6H5OSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethyl(phenoxy)silane with an assay of 97%. This is a technical grade, and TSS does not represent it as USP, BP, or EP grade.
How should Trimethyl(phenoxy)silane be handled safely?
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Trimethyl(phenoxy)silane is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
How is Trimethyl(phenoxy)silane packaged and shipped?
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Trimethyl(phenoxy)silane is shipped as a UN 1993, Class 3, Packing Group III hazardous material. TSS ensures compliant packaging and export procedures for this chemical.
How can I request a sample or quote for Trimethyl(phenoxy)silane?
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To request a sample or a quote for Trimethyl(phenoxy)silane, please contact the TSS sales team through our website or direct inquiry channels.
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