1-Acetylindoline
1-Acetylindoline (CAS 16078-30-1; C10H11NO) is a heterocyclic organic compound with a molecular weight of 161.20 g/mol. It serves as a valuable building block in organic synthesis, particularly in the preparation of various complex molecules. Its applications span the development of pharmaceutical intermediates and novel chemical entities, demonstrating its utility in advanced chemical research and development.
Preparation of Triazolothiadiazepine Dioxide Derivatives
1-Acetylindoline is utilised as a key reactant in the synthesis of triazolothiadiazepine dioxide derivatives. These compounds are of interest for their potential pharmacological activities.
Synthesis of Halo-Substituted Aromatic Amides
This compound serves as a precursor for the preparation of halo-substituted aromatic amides. This synthetic route is important for accessing diverse amide structures.
Development of Alpha-1 Adrenoreceptor Antagonists
1-Acetylindoline is employed in the synthesis of specific ethanone derivatives, such as [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone. These molecules have been investigated for their potential as alpha-1 adrenoreceptor antagonists.
Antimycobacterial Agent Synthesis
The compound is a reactant in the synthesis of naphthalenedione derivatives that exhibit antimycobacterial properties, contributing to the development of new therapeutic agents.
Regioselective Suzuki-Miyaura Coupling
1-Acetylindoline participates in regioselective ortho Suzuki-Miyaura coupling reactions. This application highlights its utility in modern cross-coupling methodologies for complex molecule construction.
| Molecular weight | 161.20 |
|---|---|
| Empirical formula | C10H11NO |
| Assay | 98% |
| Application | • Reactant for preparation of triazolothiadiazepine dioxide derivatives1• Reactant for preparation of halo-substituted aromatic amides2• Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists3• Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents4• Reactant for regioselective ortho Suzuki-Miyaura coupling reaction5 |
| Melting point | 102-104 °C(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Acetylindoline used for?
+
1-Acetylindoline is used as a reactant in the preparation of triazolothiadiazepine dioxide derivatives, halo-substituted aromatic amides, specific piperazinyl-alkyl indolyl ethanone derivatives with potential alpha-1 adrenoreceptor antagonist activity, and naphthalenedione derivatives with antimycobacterial properties. It is also employed in regioselective ortho Suzuki-Miyaura coupling reactions.
What is the CAS number and formula for 1-Acetylindoline?
+
The CAS number for 1-Acetylindoline is 16078-30-1, and its empirical formula is C10H11NO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-Acetylindoline with a minimum purity of 98%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or any pharmacopoeia grade.
How should 1-Acetylindoline be handled and stored?
+
1-Acetylindoline is classified under WGK 2 in Germany, indicating it is hazardous to water. It should be handled with appropriate personal protective equipment in a well-ventilated area. Store in a cool, dry place away from incompatible materials.
Is 1-Acetylindoline a controlled substance?
+
The provided data does not indicate that 1-Acetylindoline is a controlled substance.
How is 1-Acetylindoline packed, shipped, and exported?
+
1-Acetylindoline is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for 1-Acetylindoline?
+
To request a sample or obtain a quote for 1-Acetylindoline, please contact the Tech Serve Solutions sales team through our website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis