Trimethoprim

CAS 738-70-5C14H18N4O3Biochemicals & Reagents

Trimethoprim (CAS 738-70-5, C14H18N4O3) is a synthetic bacteriostatic agent with a molecular weight of 290.32 g/mol. It functions as an antimicrobial, primarily by inhibiting dihydrofolate reductase. This essential enzyme is crucial for bacterial DNA synthesis and survival. Trimethoprim is widely employed as an active pharmaceutical ingredient (API) in veterinary and human medicine for treating various bacterial infections.

IUPAC: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

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Trimethoprim (C14H18N4O3) — chemical structure, CAS 738-70-5; Life Science, fine chemical supplied by Tech Serve Solutions

APIs & MetabolitesAnalytical StandardsAnalytical/ChromatographyAntibacterialAntibioticsAntibiotics A to ZAntibiotics T-ZBacteriostaticBioactive Small MoleculesBiochemicals and Reagents

01 /Applications

Active Pharmaceutical Ingredient (API)

Trimethoprim serves as a critical API in the formulation of antibacterial medications. Its mechanism of action targets bacterial folic acid synthesis pathways, making it effective against a range of susceptible micro-organisms.

Veterinary Medicine

This compound is utilized in veterinary pharmaceuticals to combat bacterial infections in animals. It is often formulated in combination with sulfonamides to achieve synergistic antibacterial effects.

Analytical Standard

Trimethoprim is supplied as an analytical standard, VETRANAL™, suitable for chromatography and various analytical applications. This ensures accuracy and reliability in research and quality control processes.

02 /Properties

Molecular weight	290.32
Empirical formula	C14H18N4O3
Assay	≥98% (TLC)
Grade	VETRANAL™, analytical standard
Solubility	DMSO: soluble
Storage temperature	2-8°C
Application	Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

738-70-5

MDL number

MFCD00036761

Beilstein registry

625127

05 /Additional specifications

Gene Information	human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Trimethoprim used for?

Trimethoprim is primarily used as an active pharmaceutical ingredient (API) in antibacterial medications for both human and veterinary use. It functions as a bacteriostatic agent by inhibiting bacterial dihydrofolate reductase, essential for DNA synthesis.

What is the CAS number and formula for Trimethoprim?

The CAS number for Trimethoprim is 738-70-5, and its molecular formula is C14H18N4O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Trimethoprim as a VETRANAL™, analytical standard, with a minimum purity of ≥98% by TLC. It is not supplied as USP, BP, or EP grade unless explicitly stated.

How should Trimethoprim be handled and stored?

Handling Trimethoprim requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. It should be stored at temperatures between 2-8°C. Refer to the safety data sheet for comprehensive handling information.

Is Trimethoprim a controlled substance?

The provided data does not indicate that Trimethoprim (CAS 738-70-5) is a controlled substance. However, users should always verify local regulations.