Methyl (R)-(−)-3-hydroxy-2-methylpropionate
Methyl (R)-(−)-3-hydroxy-2-methylpropionate (CAS 72657-23-9) is a chiral building block with the molecular formula HOCH2CH(CH3)CO2CH3 and a molecular weight of 118.13 g/mol. This ester is a valuable bifunctional intermediate, essential for synthesising optically active molecules across various chemical and pharmaceutical research applications. Supplied at 99% assay, it meets stringent requirements for asymmetric synthesis.
- IUPAC
- (−)-Methyl D-β-hydroxyisobutyrate,(R)-(−)-3-Hydroxy-2-methylpropionic acid methyl ester
- Synonyms
- (−)-Methyl D-β-hydroxyisobutyrate(R)-(−)-3-Hydroxy-2-methylpropionic acid methyl ester
Asymmetric Synthesis
Serves as a key chiral building block in asymmetric synthesis, enabling the stereoselective construction of complex molecules. Its bifunctional nature allows for diverse synthetic transformations.
Pharmaceutical Intermediate
Used in the development of optically active pharmaceutical compounds. Its specific stereochemistry is crucial for the synthesis of chiral drugs and their intermediates.
Organic Synthesis
A versatile reagent in general organic synthesis for creating molecules with defined stereocentres. It is particularly useful for introducing methyl and hydroxymethyl groups with controlled chirality.
| Molecular weight | 118.13 |
|---|---|
| Linear formula | HOCH2CH(CH3)CO2CH3 |
| Assay | 99% |
| Boiling point | 76-77 °C/12 mmHg(lit.) |
| Density | 1.066 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.425(lit.) |
| Optical activity | [α]19/D −26°, c = 4 in methanol |
| Optical purity | ee: 99% (GLC) |
| Application | The (R)- and (S)-isomers are bifunctional building blocks for the synthesis of a wide variety of optically active molecules.1,2,3 |
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 80 °C / 176 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl (R)-(−)-3-hydroxy-2-methylpropionate used for?
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Methyl (R)-(−)-3-hydroxy-2-methylpropionate is a chiral building block primarily used in asymmetric synthesis and the development of optically active pharmaceutical compounds.
What is the CAS number and chemical formula?
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The CAS number is 72657-23-9, and the linear chemical formula is HOCH2CH(CH3)CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl (R)-(−)-3-hydroxy-2-methylpropionate with a minimum assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should Methyl (R)-(−)-3-hydroxy-2-methylpropionate be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields, faceshields, and suitable gloves. A full-face respirator or multi-purpose combination respirator cartridge may be necessary. The compound is flammable with a flash point of 80°C (176°F).
How is this product shipped and exported?
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This chemical is classified under NA 1993 / PGIII for transport. Tech Serve Solutions is experienced in global exporting and ensures compliance with all shipping regulations.
How can I request a sample or quote?
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To request a sample or quote for Methyl (R)-(−)-3-hydroxy-2-methylpropionate, please contact our sales team through the website or by phone.
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