Trifluoperazine dihydrochloride
Trifluoperazine dihydrochloride (CAS: 440-17-5) is a white to off-white powder with the empirical formula C21H24F3N3S · 2HCl and a molecular weight of 480.42. It is a potent antagonist of calmodulin kinase and a known inhibitor of plasma membrane calcium-ATPase (PMCA). This compound is utilized in various biological research applications, particularly in cell signaling and neuroscience studies.
- IUPAC
- 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
Calmodulin Kinase Antagonist
Trifluoperazine dihydrochloride has been employed as a calmodulin kinase antagonist in studies involving cultured neurons from Aplysia californica.
PMCA Inhibitor for Calcium Flux Studies
The compound has been used as a PMCA inhibitor in mouse duodenal tissues, effectively blocking transcellular active calcium flux in research settings.
Cell Signaling Research
Its properties as a calcium antagonist and inhibitor make it valuable for investigating intracellular calcium signaling pathways and related cellular processes.
| Molecular weight | 480.42 |
|---|---|
| Empirical formula | C21H24F3N3S · 2HCl |
| Assay | ≥99% |
| Form | powder |
| Colour | white to off-white |
| Solubility | ethanol: soluble5 mg/mLH2O: soluble50 mg/mL, clear, colorless to yellowDMSO: soluble |
| Storage temperature | −20°C |
| Melting point | 243 °C (dec.)(lit.) |
| Application | Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons1. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux2. |
| Suitability | meets USP testing specifications |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DRD2(1813) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trifluoperazine dihydrochloride used for?
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Trifluoperazine dihydrochloride is primarily used in research as a calmodulin kinase antagonist and a plasma membrane calcium-ATPase (PMCA) inhibitor, particularly in studies of cell signaling and neuroscience.
What is the CAS number and formula for Trifluoperazine dihydrochloride?
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The CAS number is 440-17-5, and the empirical formula is C21H24F3N3S · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trifluoperazine dihydrochloride with an assay of ≥99%. This product meets USP testing specifications. TSS does not claim it as USP, BP, or EP grade unless explicitly stated in the product documentation.
How should Trifluoperazine dihydrochloride be handled safely?
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Trifluoperazine dihydrochloride is classified as harmful if swallowed (H302). When handling, it is essential to wear appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Store at -20°C.
Is Trifluoperazine dihydrochloride a controlled substance?
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Based on the provided data, there is no indication that Trifluoperazine dihydrochloride is a controlled substance. However, users should always comply with local regulations.
How is Trifluoperazine dihydrochloride shipped and exported by TSS?
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As a global supplier and exporter, Tech Serve Solutions adheres to all relevant shipping and export regulations for chemical compounds like Trifluoperazine dihydrochloride.
How can I request a sample or quote for Trifluoperazine dihydrochloride?
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To request a sample or quote for Trifluoperazine dihydrochloride, please contact the Tech Serve Solutions sales team through the website or listed contact information.
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