Trifluorothymidine
Trifluorothymidine (CAS: 70-00-8), with the molecular formula C10H11F3N2O5, is a fluorinated nucleoside analog. It functions as a substrate for thymidine kinases and, upon phosphorylation, can be incorporated into DNA, leading to DNA damage. This property makes it valuable for studying DNA repair mechanisms and the mechanisms of thymidylate synthase inhibition. It is supplied by Tech Serve Solutions with an assay of ≥99% by HPLC.
- IUPAC
- α,α,α-Trifluorothymidine,2′-Deoxy-5-trifluoromethyluridine,Trifluorothymine deoxyriboside,Trifluridine
- Synonyms
- α,α,α-Trifluorothymidine2′-Deoxy-5-trifluoromethyluridineTrifluorothymine deoxyribosideTrifluridine
DNA Repair Studies
Trifluorothymidine is utilized to investigate the intricate mechanisms of DNA repair. Its incorporation into DNA and subsequent induction of DNA damage provide a direct method for observing and analysing repair pathways.
Enzyme Kinetics and Specificity
This compound serves as a substrate for studying the specificity and kinetics of thymidine kinases. Researchers can elucidate enzyme behaviour and interactions by observing its phosphorylation by these enzymes.
Thymidylate Synthase Inhibition Research
Trifluorothymidine can be employed to explore the mechanisms by which thymidylate synthase enzymes are inhibited. This aids in understanding cellular processes regulated by this enzyme.
| Molecular weight | 296.20 |
|---|---|
| Empirical formula | C10H11F3N2O5 |
| Assay | ≥99% (HPLC) |
| Storage temperature | −20°C |
| Application | Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s). |
| Melting point | 190-193 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
- H351Suspected of causing cancer
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-40 |
| Safety statements (S) | 22-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trifluorothymidine used for?
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Trifluorothymidine is used as a substrate to study thymidine kinase specificity and kinetics, to investigate DNA repair mechanisms due to its ability to induce DNA damage upon incorporation into DNA, and to study mechanisms of thymidylate synthase inhibition.
What is the CAS number and formula for Trifluorothymidine?
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The CAS number for Trifluorothymidine is 70-00-8 and its molecular formula is C10H11F3N2O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trifluorothymidine with a minimum purity of ≥99% as determined by HPLC. We do not represent this product as USP, BP, or EP grade.
How should Trifluorothymidine be handled safely?
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Handle Trifluorothymidine with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. Be aware of the associated hazards including H302, H312, H332 (Harmful if swallowed, in contact with skin, or if inhaled) and H351 (Suspected of causing cancer).
Is Trifluorothymidine suitable for export?
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Yes, Trifluorothymidine is available for global export from Tech Serve Solutions.
How can I request a sample or quote for Trifluorothymidine?
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To request a sample or a quotation for Trifluorothymidine, please contact our sales department through the website or by phone.
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