Triethyl 3-phosphonopropionate
Triethyl 3-phosphonopropionate (CAS 3699-67-0) is a valuable organic compound with the molecular formula (C2H5O)2P(O)CH2CH2CO2C2H5 and a molecular weight of 238.22 g/mol. It functions as a key reactant in various synthetic pathways. Its primary applications lie in organic synthesis, particularly in C-C bond formation and olefination reactions, making it a useful reagent for creating complex molecular structures.
- IUPAC
- 3-Phosphonopropionic acid triethyl ester,Diethyl (2-ethoxycarbonylethyl)phosphonate,Ethyl 3-(diethoxyphosphinyl)propionate,NSC 133823
- Synonyms
- 3-Phosphonopropionic acid triethyl esterDiethyl (2-ethoxycarbonylethyl)phosphonateEthyl 3-(diethoxyphosphinyl)propionateNSC 133823
Synthesis of Pharmaceutical Intermediates
Used as a reactant in the synthesis of sulfonyl hydroxamate derivatives and N-methyl-D-aspartate antagonists, which have potential applications as enzyme inhibitors and analgesics.
Horner-Wadsworth-Emmons Reagent
Serves as a reagent in Horner-Wadsworth-Emmons reactions for olefination, facilitating the formation of carbon-carbon double bonds.
Preparation of Farnesyl Phosphonate Derivatives
Acts as a reactant in the preparation of farnesyl phosphonate derivatives, which are investigated for their potential to inhibit farnesyl protein transferase.
Condensation Reactions
Employed in condensation reactions, such as with isobutyraldehyde, contributing to the construction of more complex organic molecules.
| Molecular weight | 238.22 |
|---|---|
| Linear formula | (C2H5O)2P(O)CH2CH2CO2C2H5 |
| Assay | 98% |
| Boiling point | 123-124 °C/3 mmHg(lit.) |
| Density | 1.094 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.433(lit.) |
| Application | Reactant for synthesis of: • Sulfonyl hydroxamate derivatives for use as inhibitors of class ii fructosediphosphate aldolase1• Imidazole glycerol phosphate dehydratase inhibitors2• Competitive N-methyl-D-aspartate antagonists with analgesic activity3• Farnesyl phosphonate derivatives of phenylalanine for inhibition of farnesyl protein transferase4Reactant for condensation reactions with isobutyraldehyde5 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Triethyl 3-phosphonopropionate used for?
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Triethyl 3-phosphonopropionate is used as a reactant in organic synthesis, including C-C bond formation, olefination reactions (Horner-Wadsworth-Emmons), and the synthesis of various biologically active compounds and intermediates.
What is the CAS number and chemical formula for Triethyl 3-phosphonopropionate?
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The CAS number is 3699-67-0, and the linear formula is (C2H5O)2P(O)CH2CH2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Triethyl 3-phosphonopropionate with an assay of 98%. This product is intended for research and laboratory use and is not supplied as USP, BP, or EP grade.
What are the safety and handling considerations for Triethyl 3-phosphonopropionate?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. The compound has a flash point greater than 113 °C (235.4 °F) and a WGK rating of 3 in Germany, indicating it is hazardous to water.
How is Triethyl 3-phosphonopropionate packed, shipped, and exported?
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Products are carefully packed to ensure safe transit and are exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of Triethyl 3-phosphonopropionate, please contact the Tech Serve Solutions sales team via our website or by phone.
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