2-Phenoxyphenylboronic acid
2-Phenoxyphenylboronic acid (CAS: 108238-09-1) is an organoboron compound with the formula C<sub>6</sub>H<sub>5</sub>OC<sub>6</sub>H<sub>4</sub>B(OH)<sub>2</sub> and a molecular weight of 214.02 g/mol. This aryl boronic acid serves as a key reactant in various palladium-catalyzed cross-coupling reactions and copper-mediated trifluoromethylation. It is also instrumental in the synthesis of complex molecules with potential biological and pharmacological activity. Tech Serve Solutions supplies this reagent for research and chemical synthesis applications.
Palladium-Catalyzed Cross-Coupling Reactions
2-Phenoxyphenylboronic acid is a valuable substrate for Suzuki-Miyaura cross-coupling reactions, enabling the formation of new carbon-carbon bonds. This is widely employed in the synthesis of complex organic molecules.
Copper-Mediated Trifluoromethylation
This compound can participate in copper-mediated oxidative cross-coupling reactions to introduce trifluoromethyl groups. This process is significant for modifying the properties of organic molecules.
Synthesis of Biologically Active Molecules
The unique structure of 2-phenoxyphenylboronic acid makes it a useful building block for preparing compounds with potential pharmacological applications. Its derivatives have been explored for medicinal chemistry.
Preparation of Pyridazine Scaffolds
It serves as a precursor in the synthesis of pyridazine-based scaffolds, which are investigated as mimetics for alpha-helices in biological systems.
| Molecular weight | 214.02 |
|---|---|
| Linear formula | C6H5OC6H4B(OH)2 |
| Application | Reactant for:• Palladium catalyzed cross-coupling reactions1• Trifluoromethylation via copper-mediated oxidative cross-coupling2• Preparation of biologically and pharmacologically active molecules3,4• Preparation of pyridazine-based scaffolds as a-helix mimetics5 |
| Melting point | 104-108 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Phenoxyphenylboronic acid used for?
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2-Phenoxyphenylboronic acid is primarily used as a reactant in palladium-catalyzed cross-coupling reactions, copper-mediated trifluoromethylation, and for the preparation of biologically active molecules and pyridazine-based scaffolds.
What are the CAS number and chemical formula for 2-Phenoxyphenylboronic acid?
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The CAS number is 108238-09-1, and the chemical formula is C<sub>6</sub>H<sub>5</sub>OC<sub>6</sub>H<sub>4</sub>B(OH)<sub>2</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Phenoxyphenylboronic acid for research and chemical synthesis. The specific assay and purity are detailed in the product's specification sheet. TSS does not represent this product as USP, BP, or EP grade.
How should 2-Phenoxyphenylboronic acid be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Please consult the Safety Data Sheet for comprehensive safety information.
Does Tech Serve Solutions export 2-Phenoxyphenylboronic acid?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Phenoxyphenylboronic acid.
How can I request a quote or sample for 2-Phenoxyphenylboronic acid?
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Please contact our sales department via the website or phone to request a quote or a sample of 2-Phenoxyphenylboronic acid.
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