Triciribine hydrate

CAS 35943-35-2 (anhydrous)C13H16N6O4 · xH2OCell Biology

Triciribine hydrate (CAS: 35943-35-2) is a chemical compound with the formula C13H16N6O4 · xH2O. This tan powder, with a molecular weight of 320.30 g/mol on an anhydrous basis, is primarily utilised in biochemical research. Its applications include the study of cellular processes, signalling pathways, and kinase inhibition, making it a valuable tool for researchers in cell biology and neuroscience.

IUPAC: API-2,Akt/PKB Signaling Inhibitor-2,Inhibitor V,NSC 154020,TCN,VD-0002

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Triciribine hydrate (C13H16N6O4 · xH2O) — chemical structure, CAS 35943-35-2 (anhydrous); Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyKinase/Phosphatase BiologyProtein Kinase B (Akt/PKB)T More...

01 /Applications

Investigating MMP-1 Activity

Triciribine hydrate has been employed in studies to examine the influence of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) within hepatic stellate cells.

Analyzing ADAM 10 Activation

It has also been utilised to investigate the activation mechanisms of ADAM 10, particularly in N2a cells that overexpress the Swedish mutant of amyloid precursor protein (SweAPP N2a cells), when exposed to (-)-epigallocatechin-3-gallate (EGCG).

Cellular Signaling Research

As a bioactive small molecule, Triciribine hydrate serves as a tool for exploring complex cellular signalling pathways, including those involving Protein Kinase B (Akt/PKB).

02 /Properties

Molecular weight	320.30 (anhydrous basis)
Empirical formula	C13H16N6O4 · xH2O
Assay	≥97% (HPLC)
Form	powder
Colour	tan
Solubility	DMSO: >10 mg/mL
Storage temperature	2-8°C
Application	Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.

03 /Identifiers & registry

CAS number

35943-35-2 (anhydrous)

04 /Additional specifications

Gene Information	human ... AKT1(207)mouse ... AKT1(11651)rat ... AKT1(24185)

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Triciribine hydrate used for?

Triciribine hydrate is used in research to study cellular processes, signalling pathways, and kinase inhibition, including its effects on MMP-1 and ADAM 10 activation.

What is the CAS number and formula for Triciribine hydrate?

The CAS number for the anhydrous form is 35943-35-2, and the formula is C13H16N6O4 · xH2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Triciribine hydrate with a purity of ≥97% (HPLC). This product is intended for research use and is not represented as USP, BP, or EP grade.

How should Triciribine hydrate be handled safely?

According to GHS classifications, Triciribine hydrate has a WGK Germany rating of 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area.