Triamterene
Triamterene (CAS: 396-01-0), a pteridine derivative with the molecular formula C12H11N7, is a bioactive small molecule with applications in cell biology and ion channel research. It has been utilised in studies investigating urokinase receptor induction in podocytes and as an activator compound identified through biochemical screening. Its molecular weight is 253.26 g/mol. TSS supplies this compound for research and development purposes.
- IUPAC
- 2,4,7-Triamino-6-phenylpteridine,6-Phenyl-2,4,7-pteridinetriamine
- Synonyms
- 2,4,7-Triamino-6-phenylpteridine6-Phenyl-2,4,7-pteridinetriamine
Research in Podocyte Biology
Triamterene has been employed in <i>in vitro</i> studies to investigate its role in the induction of urokinase receptor (uPAR) in podocytes, contributing to the understanding of renal cell biology.
Biochemical Assay Screening
This compound was identified as an activator from a library screen using a fluorogenic α-glucosidase assay, highlighting its potential as a tool in biochemical research and drug discovery.
Ion Channel Modulation Studies
Classified under voltage-gated ion channels and specifically as a sodium channel modulator, Triamterene is relevant for research into ion channel function and related physiological processes.
| Molecular weight | 253.26 |
|---|---|
| Empirical formula | C12H11N7 |
| Assay | ≥99% |
| Solubility | formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble1.2 mg/mLDMSO: soluble5.4 mg/mLH2O: insoluble |
| Application | Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Triamterene used for?
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Triamterene is used for research purposes, including studies on urokinase receptor (uPAR) induction in podocytes and as an activator compound identified in biochemical screening assays. It is also studied for its role in ion channel modulation.
What is the CAS number and formula for Triamterene?
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The CAS number for Triamterene is 396-01-0, and its empirical formula (Hill notation) is C12H11N7.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Triamterene with an assay of ≥99%. This product is supplied for research use only and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling recommendations for Triamterene?
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Triamterene is classified with a GHS07 symbol and a 'Warning' signal word. It carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment includes a dust mask type N95 (US), eyeshields, faceshields, and gloves. Handle in a well-ventilated area and avoid dust formation.
How is Triamterene packed and exported?
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Triamterene is available for global export. Products are carefully packed according to industry standards to ensure safe transit and compliance with international shipping regulations.
How can I request a sample or quote for Triamterene?
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To request a sample or a quote for Triamterene, please contact our sales team via the website or email. Please specify the quantity required and your delivery location.
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