Trichloroacetic anhydride
Trichloroacetic anhydride (CAS 4124-31-6) is a reactive organic compound with the linear formula (Cl3CCO)2O and a molecular weight of 308.76 g/mol. This powerful acylating agent is primarily employed as a building block in organic synthesis and for the preparation of various chemical intermediates. Its utility is rooted in its ability to introduce the trichloroacetyl group into other molecules, facilitating diverse chemical transformations within industrial and research settings.

Organic Synthesis Reagent
Trichloroacetic anhydride serves as a key reagent in organic synthesis, enabling the introduction of the trichloroacetyl group into various substrates. This functionality is valuable for constructing complex organic molecules and modifying existing chemical structures.
Intermediate in Chemical Manufacturing
It acts as an important intermediate in the production of fine chemicals and pharmaceutical precursors. Its reactivity allows for controlled chemical modifications crucial for multi-step synthesis pathways.
Acylating Agent
The compound functions effectively as an acylating agent, reacting with nucleophiles such as alcohols and amines. This characteristic is exploited in specific esterification and amidation reactions within chemical research and development.
| Molecular weight | 308.76 |
|---|---|
| Linear formula | (Cl3CCO)2O |
| Assay | ≥98.0% (T) |
| Boiling point | 139-141 °C/60 mmHg(lit.) |
| Density | 1.69 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.484(lit.)n20/D 1.485 |


Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-35 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trichloroacetic anhydride used for?
+
Trichloroacetic anhydride is primarily used as a reagent in organic synthesis and as a building block for chemical intermediates. It functions as an acylating agent to introduce the trichloroacetyl group into molecules.
What is the CAS number and formula for Trichloroacetic anhydride?
+
The CAS number for Trichloroacetic anhydride is 4124-31-6 and its linear formula is (Cl3CCO)2O.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Trichloroacetic anhydride with an assay of ≥98.0% (T). We do not represent this product as USP, BP, or EP grade.
What are the primary safety hazards associated with Trichloroacetic anhydride?
+
Trichloroacetic anhydride is classified as Danger, with hazards including H302 (Harmful if swallowed) and H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, such as gloves, goggles, and respiratory protection, is essential during handling.
How is Trichloroacetic anhydride packed and shipped?
+
Trichloroacetic anhydride is shipped as UN 3265, Class 8, Packing Group II, indicating it is a corrosive solid. Packaging adheres to strict international regulations for hazardous materials to ensure safe transport and export.
How can I request a sample or quote for Trichloroacetic anhydride?
+
To request a sample or a quotation for Trichloroacetic anhydride, please contact our sales department through the TSS website or your dedicated account manager.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis