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Trichloroacetic anhydride

CAS 4124-31-6(Cl3CCO)2OChemical Synthesis

Trichloroacetic anhydride (CAS 4124-31-6) is a reactive organic compound with the linear formula (Cl3CCO)2O and a molecular weight of 308.76 g/mol. This powerful acylating agent is primarily employed as a building block in organic synthesis and for the preparation of various chemical intermediates. Its utility is rooted in its ability to introduce the trichloroacetyl group into other molecules, facilitating diverse chemical transformations within industrial and research settings.

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Trichloroacetic anhydride ((Cl3CCO)2O) — chemical structure, CAS 4124-31-6; Chemistry, fine chemical supplied by Tech Serve Solutions
Building BlocksCarbonyl CompoundsCarboxylic Acid AnhydridesChemical SynthesisOrganic Building Blocks
01 /Applications

Organic Synthesis Reagent

Trichloroacetic anhydride serves as a key reagent in organic synthesis, enabling the introduction of the trichloroacetyl group into various substrates. This functionality is valuable for constructing complex organic molecules and modifying existing chemical structures.

Intermediate in Chemical Manufacturing

It acts as an important intermediate in the production of fine chemicals and pharmaceutical precursors. Its reactivity allows for controlled chemical modifications crucial for multi-step synthesis pathways.

Acylating Agent

The compound functions effectively as an acylating agent, reacting with nucleophiles such as alcohols and amines. This characteristic is exploited in specific esterification and amidation reactions within chemical research and development.

02 /Properties
Molecular weight308.76
Linear formula(Cl3CCO)2O
Assay≥98.0% (T)
Boiling point139-141 °C/60 mmHg(lit.)
Density1.69 g/mL at 25 °C(lit.)
Refractive indexn20/D 1.484(lit.)n20/D 1.485
03 /Safety & handling
GHS hazard pictogram: Corrosive (GHS05)
Corrosive
GHS hazard pictogram: Harmful / irritant (GHS07)
Harmful / irritant
Danger

Hazard statements

  • H302Harmful if swallowed
  • H314Causes severe skin burns and eye damage

Precautionary statements

  • P280Wear protective gloves, clothing and eye/face protection
  • P305IF IN EYES
  • P310Immediately call a POISON CENTER or doctor
Protective equipmentFaceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Transport (UN / ADR)UN 3265 8 / PGII
Water hazard class (WGK, DE)3
Hazard codes (EU)C
Risk statements (R)22-35
Safety statements (S)26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry
CAS number
4124-31-6
MDL number
MFCD00000793
PubChem substance
24889464
Beilstein registry
980355
05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Trichloroacetic anhydride used for?

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Trichloroacetic anhydride is primarily used as a reagent in organic synthesis and as a building block for chemical intermediates. It functions as an acylating agent to introduce the trichloroacetyl group into molecules.

What is the CAS number and formula for Trichloroacetic anhydride?

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The CAS number for Trichloroacetic anhydride is 4124-31-6 and its linear formula is (Cl3CCO)2O.

What grade and purity does Tech Serve Solutions supply?

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Tech Serve Solutions supplies Trichloroacetic anhydride with an assay of ≥98.0% (T). We do not represent this product as USP, BP, or EP grade.

What are the primary safety hazards associated with Trichloroacetic anhydride?

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Trichloroacetic anhydride is classified as Danger, with hazards including H302 (Harmful if swallowed) and H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, such as gloves, goggles, and respiratory protection, is essential during handling.

How is Trichloroacetic anhydride packed and shipped?

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Trichloroacetic anhydride is shipped as UN 3265, Class 8, Packing Group II, indicating it is a corrosive solid. Packaging adheres to strict international regulations for hazardous materials to ensure safe transport and export.

How can I request a sample or quote for Trichloroacetic anhydride?

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To request a sample or a quotation for Trichloroacetic anhydride, please contact our sales department through the TSS website or your dedicated account manager.

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