Tri-n-butyllithium magnesate
Tri-n-butyllithium magnesate (CAS 20910-20-7), empirical formula C12H27LiMg and molecular weight 202.59 g/mol, is an organometallic reagent. It is typically supplied as a solution in diethyl ether/hexanes. This compound serves as a valuable reagent in organic synthesis, particularly for reactions requiring a strong, bulky base or nucleophile.
- IUPAC
- Lithium tributylmagnesate in hexanes/ether
Organometallic Synthesis
Tri-n-butyllithium magnesate acts as a potent nucleophile and base in various organic transformations. Its sterically hindered nature allows for selective reactions, making it useful in the formation of complex carbon-carbon bonds.
Deprotonation Reactions
The strong basicity of this reagent facilitates the deprotonation of weakly acidic protons. This is crucial in generating enolates and other carbanions for subsequent synthetic steps in complex molecule construction.
Grignard Reagent Chemistry
As a mixed magnesium-lithium reagent, it can exhibit reactivity profiles distinct from simple Grignard or organolithium compounds. This allows for tailored synthetic strategies in pharmaceutical and fine chemical manufacturing.
| Molecular weight | 202.59 |
|---|---|
| Empirical formula | C12H27LiMg |
| Density | 0.769 g/mL at 25 °C |
| Concentration | 0.7 M in diethyl ether/hexanes |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H304May be fatal if swallowed and enters airways
- H315Causes skin irritation
- H336May cause drowsiness or dizziness
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P301IF SWALLOWED
- P331Do NOT induce vomiting
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -25 °C / -13 °F |
| Transport (UN / ADR) | UN 1155 3/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn,N |
| Risk statements (R) | 11-14-19-22-38-51/53-65-67 |
| Safety statements (S) | 16-61-62 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tri-n-butyllithium magnesate used for?
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Tri-n-butyllithium magnesate (CAS 20910-20-7) is primarily used as a strong organometallic base and nucleophile in organic synthesis, facilitating deprotonation and carbon-carbon bond formation.
What is the CAS number and formula for Tri-n-butyllithium magnesate?
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The CAS number is 20910-20-7 and the empirical formula (Hill notation) is C12H27LiMg.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tri-n-butyllithium magnesate at a concentration of 0.7 M in diethyl ether/hexanes. We do not represent this product as USP, BP, or EP grade.
How should Tri-n-butyllithium magnesate be handled and stored?
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This compound is highly flammable (flash point -25 °C) and reacts with moisture. It may form explosive peroxides. Store at 2-8°C, away from ignition sources and incompatible materials. Handle under an inert atmosphere with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator.
Is Tri-n-butyllithium magnesate a controlled substance?
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The provided safety data does not indicate that Tri-n-butyllithium magnesate is a controlled substance.
How is Tri-n-butyllithium magnesate packed and shipped?
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Tri-n-butyllithium magnesate is shipped as a UN 1155, Hazard Class 3, Packing Group I. Packaging adheres to strict regulations for flammable liquids. TSS is an experienced global exporter.
How can I request a quote or sample?
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Please contact our sales team via the website or direct inquiry to request a quote or sample of Tri-n-butyllithium magnesate.
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