Tri(2-furyl)phosphine
Tri(2-furyl)phosphine (CAS: 5518-52-5, Formula: C12H9O3P, MW: 232.17) is a phosphine ligand frequently employed in organic synthesis. It functions as a key component in various transition-metal catalysed cross-coupling reactions. Its unique electronic and steric properties make it valuable for facilitating challenging chemical transformations.
- IUPAC
- TFP,Tri-2-furanylphosphine,Tris(2-furanyl)phosphine,Tris(o-furyl)phosphine
- Synonyms
- TFPTri-2-furanylphosphineTris(2-furanyl)phosphineTris(o-furyl)phosphine
Catalysis in Cross-Coupling Reactions
Tri(2-furyl)phosphine is widely utilized as a ligand in palladium-catalysed cross-coupling reactions. It promotes efficient bond formation in processes such as Suzuki-Miyaura, Sonogashira, Heck, and Buchwald-Hartwig amination reactions.
Ligand for Organometallic Chemistry
This phosphine serves as a versatile ligand in organometallic chemistry, coordinating with various transition metals. It plays a role in catalytic cycles for cycloisomerizations and other transformations.
Synthesis of Complex Organic Molecules
Its application extends to the synthesis of complex organic molecules, where precise control over catalytic activity is required. It is particularly useful in Negishi and Stille coupling reactions.
Use in Oxidation Catalysis
Tri(2-furyl)phosphine can also function as a ligand in certain oxidation catalysis systems, contributing to diverse synthetic methodologies.
| Molecular weight | 232.17 |
|---|---|
| Empirical formula | C12H9O3P |
| Assay | 99% |
| Boiling point | 136 °C/4 mmHg(lit.) |
| Melting point | 59-64 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionCycloisomerizationsHeck ReactionNegishi CouplingOxidationsSonogashira CouplingStille CouplingSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tri(2-furyl)phosphine used for?
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Tri(2-furyl)phosphine is primarily used as a phosphine ligand in various transition-metal catalysed organic reactions, including cross-coupling reactions like Suzuki-Miyaura, Sonogashira, Heck, and Buchwald-Hartwig amination, as well as in cycloisomerizations and oxidations.
What are the CAS number and formula for Tri(2-furyl)phosphine?
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The CAS number for Tri(2-furyl)phosphine is 5518-52-5, and its empirical formula is C12H9O3P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tri(2-furyl)phosphine with an assay of 99%. We do not represent this product as USP, EP, or BP grade.
How should Tri(2-furyl)phosphine be handled safely?
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Tri(2-furyl)phosphine is classified as a Warning substance (GHS07) with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. In case of eye contact, rinse cautiously with water for several minutes; remove contact lenses if present and easy to do. Continue rinsing.
Is Tri(2-furyl)phosphine a controlled substance?
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The provided data does not indicate that Tri(2-furyl)phosphine is a controlled substance.
How is Tri(2-furyl)phosphine packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports chemicals globally, adhering to all necessary regulations for safe and compliant transport.
How can I request a quote or sample of Tri(2-furyl)phosphine?
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To request a quote or sample of Tri(2-furyl)phosphine, please contact our sales team via the website or directly via email or phone.
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