trans-4-(Trifluoromethyl)cinnamic acid

CAS 16642-92-5CF3C6H4CH=CHCO2HChemical Synthesis

trans-4-(Trifluoromethyl)cinnamic acid (CAS: 16642-92-5) is an organic compound with the linear formula CF3C6H4CH=CHCO2H and a molecular weight of 216.16 g/mol. This carboxylic acid derivative is characterised by a trifluoromethyl group and a trans-configured double bond conjugated to the aromatic ring and carboxylate moiety. It is primarily utilised as a building block in chemical synthesis and research applications, particularly in analytical chemistry.

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trans-4-(Trifluoromethyl)cinnamic acid (CF3C6H4CH=CHCO2H) — chemical structure, CAS 16642-92-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC10Carbonyl CompoundsCarboxylic AcidsChemical Synthesis

01 /Applications

Internal Standard in HPLC Analysis

trans-4-(Trifluoromethyl)cinnamic acid has been employed as an internal standard for the accurate determination of A77 1726 (2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide) in plasma samples using High-Performance Liquid Chromatography (HPLC).

Organic Synthesis Building Block

As a functionalised cinnamic acid derivative, this compound serves as a versatile building block in organic synthesis. Its structure allows for various chemical transformations, contributing to the development of more complex molecules.

Research and Development

This chemical is valuable in research settings for exploring new synthetic pathways and developing novel compounds. Its specific structural features make it of interest in medicinal chemistry and materials science research.

02 /Properties

Molecular weight	216.16
Linear formula	CF3C6H4CH=CHCO2H
Assay	99%
Application	trans-4-(Trifluoromethyl)cinnamic acid has been employed as internal standard for the determination of A77 1726 (2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide) in plasma by HPLC1.
Melting point	231-233 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-37/39

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

16642-92-5

MDL number

MFCD00002696

PubChem substance

24853951

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is trans-4-(Trifluoromethyl)cinnamic acid used for?

trans-4-(Trifluoromethyl)cinnamic acid is used as an internal standard in analytical techniques like HPLC and as a building block in organic synthesis for research and development purposes.

What are the CAS number and formula for trans-4-(Trifluoromethyl)cinnamic acid?

The CAS number is 16642-92-5, and its linear formula is CF3C6H4CH=CHCO2H.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies trans-4-(Trifluoromethyl)cinnamic acid with a minimum purity of 99%. This product is suitable for laboratory research and chemical synthesis. TSS does not represent this product as USP, BP, EP or any other pharmacopoeia grade.

How should trans-4-(Trifluoromethyl)cinnamic acid be handled?

Handle trans-4-(Trifluoromethyl)cinnamic acid with appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves. Ensure adequate ventilation. Avoid breathing dust and direct contact with skin and eyes, as it may cause skin irritation, eye irritation, and respiratory irritation (H315-H319-H335).

Is trans-4-(Trifluoromethyl)cinnamic acid available for export?

Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including trans-4-(Trifluoromethyl)cinnamic acid, serving customers worldwide.

How can I request a quote or sample?

To request a quote or sample of trans-4-(Trifluoromethyl)cinnamic acid, please visit the product page on the Tech Serve Solutions website and use the designated contact or inquiry forms.