trans-4-(tert-Butyldimethylsiloxy)-1-buten-1-ylboronic acid pinacol ester
trans-4-(tert-Butyldimethylsiloxy)-1-buten-1-ylboronic acid pinacol ester (CAS: 480425-30-7) is an organoboron compound with the formula C16H33BO3Si and a molecular weight of 312.33 g/mol. It is a versatile building block used in organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling. Its protected hydroxyl group and vinyl boronate functionality make it valuable for constructing complex organic molecules in research and development.
- IUPAC
- trans-2-[4-(tert-butyldimethylsilyloxy)-1-buten-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Synonyms
- trans-2-[4-(tert-butyldimethylsilyloxy)-1-buten-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Suzuki-Miyaura Cross-Coupling
This compound serves as a key coupling partner in Suzuki-Miyaura reactions, enabling the formation of carbon-carbon bonds. The vinyl boronate moiety readily participates in palladium-catalyzed couplings with aryl and vinyl halides or triflates.
Organic Synthesis Intermediate
Its unique structure, featuring a protected alcohol and a vinyl boronate ester, makes it an important intermediate in multi-step syntheses. It can be used to introduce functionalized butenyl chains into various molecular frameworks.
Pharmaceutical Research
This reagent finds application in medicinal chemistry for the synthesis of novel drug candidates. Its ability to participate in efficient C-C bond formation is crucial for building complex scaffolds with potential therapeutic properties.
Materials Science
The compound can be employed in the synthesis of specialized organic materials, where the introduction of specific functional groups or chain lengths is required for desired material properties.
| Molecular weight | 312.33 |
|---|---|
| Empirical formula | C16H33BO3Si |
| Assay | 95% |
| Boiling point | 297-298 °C(lit.) |
| Density | 0.888 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4470(lit.) |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is trans-4-(tert-Butyldimethylsiloxy)-1-buten-1-ylboronic acid pinacol ester used for?
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This compound is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions and the construction of complex organic molecules in pharmaceutical research and materials science.
What is the CAS number and formula for this product?
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The CAS number is 480425-30-7 and the empirical formula is C16H33BO3Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations?
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This compound requires the use of eyeshields and gloves for safe handling. It has a flash point above 110 °C (230 °F) and is classified under WGK 2 in Germany.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents.
How can I request a sample or quote?
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To request a sample or a quote, please contact our sales team through the website or by calling our customer service number.
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