Topotecan hydrochloride hydrate
Topotecan hydrochloride hydrate (CAS: 123948-87-8) is a topoisomerase I inhibitor. This yellow, powdered compound, with a molecular weight of 421.45 g/mol (anhydrous free base), is supplied by Tech Serve Solutions for research applications. It has been utilized as a positive control in studies investigating inhibitors of HIF-1α and VEGF, and in in vitro apoptosis assays, contributing to advancements in cell biology and cancer research.
- IUPAC
- 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate,NSC-609669 hydrochloride hydrate,SKF-104864A hydrochloride hydrate,hycamptamine hydrochloride hydrate
- Synonyms
- 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrateNSC-609669 hydrochloride hydrateSKF-104864A hydrochloride hydratehycamptamine hydrochloride hydrate
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Apoptosis Assays
Topotecan hydrochloride hydrate has been employed in in vitro apoptosis assays, specifically in PA317 cells, to study programmed cell death mechanisms.
HIF-1α and VEGF Inhibition Studies
It serves as a positive control in the identification and analysis of inhibitors targeting HIF-1α and VEGF in human glioma cells under hypoxic conditions.
Cancer Research Tool
As a bioactive small molecule and DNA repair regulator, it is a valuable reagent for research into cell cycle regulation and DNA metabolism in oncology.
| Molecular weight | 421.45 (anhydrous free base basis) |
|---|---|
| Empirical formula | C23H23N3O5 · xHCl · yH2O |
| Assay | ≥98% (HPLC and enzymatic) |
| Form | powder |
| Colour | yellow |
| Solubility | DMSO: ≥20 mg/mL |
| Storage temperature | −20°C |
| Application | Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions1. It has also been used for in vitro apoptosis assays in PA317 cells2. |
Hazard statements
- H341Suspected of causing genetic defects
Precautionary statements
- P281Use personal protective equipment as required
| Transport (UN / ADR) | UN 2811 6.1/PG 3 |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 46-48 |
| Safety statements (S) | 22-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccatedprotect from light |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Topotecan hydrochloride hydrate used for?
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Topotecan hydrochloride hydrate is used in research as a positive control for identifying and analysing HIF-1α and VEGF inhibitors, and for in vitro apoptosis assays. It is also a tool for studying DNA repair and cell cycle regulation.
What is the CAS number and formula for Topotecan hydrochloride hydrate?
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The CAS number for the free base is 123948-87-8. The empirical formula is C23H23N3O5 · xHCl · yH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Topotecan hydrochloride hydrate with an assay of ≥98% (HPLC and enzymatic). This product is intended for research and laboratory use and is not represented as USP, BP, or EP grade.
How should Topotecan hydrochloride hydrate be handled and stored?
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Topotecan hydrochloride hydrate is classified under GHS08 with a 'Warning' signal word, carrying hazard statement H341. It requires careful handling in a desiccated state, protected from light, and stored at -20°C. Always use appropriate personal protective equipment (P281).
How is Topotecan hydrochloride hydrate shipped and exported?
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Topotecan hydrochloride hydrate is shipped as UN 2811, Class 6.1, Packing Group 3. Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or quote for Topotecan hydrochloride hydrate?
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Please contact our sales team directly through our website to request a sample or obtain a quotation for Topotecan hydrochloride hydrate.
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