Tetramethyl-d12 orthosilicate
Tetramethyl-d12 orthosilicate (CAS 80396-70-9) is a deuterated organosilicon compound with the linear formula (OCD3)4Si and a molecular weight of 164.30. It serves as a valuable precursor and reagent in various advanced scientific fields. This deuterated analogue of tetramethyl orthosilicate is particularly useful in applications requiring isotopic labelling for analytical or mechanistic studies. Its unique structure makes it suitable for chemical synthesis and materials science research.
- IUPAC
- Tetramethoxy-d12-silane
- Synonyms
- Tetramethoxy-d12-silaneOrthosilic acid tetrakis(trideuteromethyl) esterSilicon tetrakis(trideuteromethoxy) ether

Isotopic Labelling
Tetramethyl-d12 orthosilicate is employed in chemical synthesis to introduce deuterium atoms into organic and organometallic molecules. This isotopic labelling is crucial for spectroscopic analysis, reaction mechanism studies, and metabolic tracking in biochemical research.
Materials Science Research
The compound can be utilized as a precursor in materials science for the development of novel silicon-based materials. Its deuterated nature may offer specific advantages in studies involving material degradation or diffusion processes where isotopic tracing is beneficial.
Chemical Synthesis Reagent
As an organosilicon reagent, it participates in various synthetic transformations. The presence of deuterium can help elucidate reaction pathways and confirm structural assignments through mass spectrometry and NMR spectroscopy.
Precursor for Thin Film Deposition
Tetramethyl-d12 orthosilicate may serve as a precursor in solution deposition techniques for creating thin films. The deuterated form can be used in advanced research to study film growth mechanisms and properties with enhanced analytical capabilities.
| Molecular weight | 164.30 |
|---|---|
| Linear formula | (OCD3)4Si |
| Density | 1.114 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.366(lit.) |



Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | 29 °C / 84.2 °F |
|---|---|
| Transport (UN / ADR) | UN 2606 3(6.1) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-23-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | mol wt 164.18 by atom % calculation |
|---|---|
| Isotopic Purity | 99 atom % D |
| Mass Shift | M+12 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetramethyl-d12 orthosilicate used for?
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Tetramethyl-d12 orthosilicate is primarily used for isotopic labelling in chemical synthesis, materials science research, and as a precursor in thin film deposition studies where deuterium incorporation is beneficial for analytical purposes.
What is the CAS number and formula for Tetramethyl-d12 orthosilicate?
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The CAS number is 80396-70-9 and the linear formula is (OCD3)4Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetramethyl-d12 orthosilicate with a 99 atom % D isotopic purity. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Tetramethyl-d12 orthosilicate be handled safely?
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Tetramethyl-d12 orthosilicate is a flammable liquid and vapour (H226), causes severe skin burns and eye damage (H314), and is toxic if inhaled (H331). Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment including gloves, eye protection, and respiratory protection. Refer to the Safety Data Sheet for full handling procedures.
Is Tetramethyl-d12 orthosilicate shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Tetramethyl-d12 orthosilicate, and ships products worldwide.
How can I request a quote or sample?
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To request a quote or a sample of Tetramethyl-d12 orthosilicate, please contact the Tech Serve Solutions sales team via our website or direct contact details.
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