Tetrabutylammonium fluoride solution
Tetrabutylammonium fluoride solution (CAS: 429-41-4, Formula: [CH3(CH2)3]4NF, MW: 261.46) is a versatile reagent, typically supplied as approximately 1M in THF with 4-5% water. Its primary utility lies in organic synthesis, acting as a fluoride source and deprotecting agent. It is instrumental in the preparation of complex molecules, including novel antidepressants, alcohols via silyl ether hydrolysis, and various pharmaceutical intermediates, making it a valuable component in advanced chemical research and development.
- IUPAC
- TBAF solution
![Tetrabutylammonium fluoride solution ([CH3(CH2)3]4NF) — chemical structure, CAS 429-41-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F429-41-4.png&w=3840&q=75)
Preparation of Novel Antidepressants
Serves as a key reactant in synthesising triple monoamine reuptake inhibitors, representing a new generation of antidepressant therapies.
Hydrolysis of Alkyl Silyl Ethers
Facilitates the preparation of alcohols through the hydrolysis of alkyl silyl ethers under neutral pH conditions in buffered aqueous-organic mixtures.
Synthesis of Oligoribonucleotides
Employed in the synthesis of oligoribonucleotides that feature phosphonate-modified linkages, crucial for nucleic acid research.
Nozaki-Hiyama Allylation Reactions
Used in the synthesis of aryl alkyl alcohols via Nozaki-Hiyama allylation, catalysed by specific chiral bipyridyldiol ligands and chromium trichloride.
Suzuki Coupling Reactions
A reactant in the synthesis of conjugated dienoic acid esters through established Suzuki coupling methodologies.
Synthesis of Biologically Active Compounds
Involved in synthesising macrocyclic o-aminobenzamide Hsp90 inhibitors with demonstrated antitumor activity and anti-diabetic polyacetylenic glucosides.
| Molecular weight | 261.46 |
|---|---|
| Linear formula | [CH3(CH2)3]4NF |
| Concentration | ~1 M in THF |
| Storage temperature | 2-8°C |
| Impurities tested | 4-5% water |
| Application | Reactant for preparation of:• Triple monoamine reuptake inhibitors as a new generation of antidepressants1• Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions2• Oligoribonucleotides with phosphonate-modified linkages3• Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride4• Conjugated dienoic acid esters using Suzuki coupling reactions5• Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity6• Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors7• Anti-diabetic polyacetylenic glucosides8 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetrabutylammonium fluoride solution used for?
+
Tetrabutylammonium fluoride solution is primarily used as a reagent in organic synthesis for deprotection, as a fluoride source, and in the preparation of various complex molecules including pharmaceuticals and advanced materials.
What are the CAS number and formula for Tetrabutylammonium fluoride solution?
+
The CAS number for Tetrabutylammonium fluoride solution is 429-41-4, and its linear formula is [CH3(CH2)3]4NF.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Tetrabutylammonium fluoride solution typically at approximately 1M in THF with 4-5% water. TSS does not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with Tetrabutylammonium fluoride solution?
+
Tetrabutylammonium fluoride solution is flammable (H225) and corrosive (H314), causing severe skin burns and eye damage. It may also cause respiratory irritation (H335) and is suspected of causing cancer (H351). It may form explosive peroxides. Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment.
How is Tetrabutylammonium fluoride solution packaged and shipped?
+
Tetrabutylammonium fluoride solution is packaged according to UN 2924, Class 8(3), Packing Group II specifications for hazardous materials shipping. It is stored under refrigeration at 2-8°C.
How can I request a quote or sample of Tetrabutylammonium fluoride solution?
+
To request a quote or sample of Tetrabutylammonium fluoride solution, please contact our sales department through the TSS website or via direct inquiry, specifying the product details and quantity required.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis