tert-Butyl carbamate

CAS 4248-19-5NH2COOC(CH3)3Chemical Synthesis

Tert-Butyl carbamate (CAS: 4248-19-5) is a valuable organic building block and protected amine, featuring the linear formula NH2COOC(CH3)3 and a molecular weight of 117.15 g/mol. It plays a key role in chemical synthesis, particularly as a reagent in palladium-catalyzed reactions and the construction of heterocyclic compounds. Its protected amine functionality makes it ideal for selective modifications in complex organic chemistry pathways.

IUPAC: Boc-amide

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tert-Butyl carbamate (NH2COOC(CH3)3) — chemical structure, CAS 4248-19-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksChemical SynthesisNitrogen CompoundsOrganic Building BlocksProtected Amines

01 /Applications

Palladium-Catalyzed Synthesis

Tert-Butyl carbamate serves as a reagent in palladium-catalyzed reactions for the synthesis of N-Boc-protected anilines. This application is crucial in multi-step organic syntheses where amine protection is required.

Heterocyclic Compound Synthesis

It is employed in the synthesis of substituted pyrroles, specifically those functionalised with ester or ketone groups at the C-3 position. This facilitates the creation of diverse heterocyclic scaffolds.

Amine Protection

As a Boc-protected amine, tert-Butyl carbamate is widely used to introduce the tert-butyloxycarbonyl (Boc) protecting group onto amines. This is a common strategy in peptide synthesis and other organic transformations.

02 /Properties

Molecular weight	117.15
Linear formula	NH2COOC(CH3)3
Assay	98%
Application	tert-Butyl carbamate was used in palladium-catalyzed synthesis of N-Boc-protected anilines1. It was used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position2.
Melting point	105-108 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

4248-19-5

MDL number

MFCD00007962

PubChem substance

24850207

Beilstein registry

1744500

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is tert-Butyl carbamate used for?

Tert-Butyl carbamate is used in chemical synthesis, particularly in palladium-catalyzed reactions to form N-Boc-protected anilines and in the synthesis of functionalized pyrroles. It acts as a protected amine building block.

What is the CAS number and formula for tert-Butyl carbamate?

The CAS number for tert-Butyl carbamate is 4248-19-5, and its linear formula is NH2COOC(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies tert-Butyl carbamate with an assay of 98%. This is a technical grade, and TSS does not represent it as USP, BP, or EP.

What are the safety and handling precautions for tert-Butyl carbamate?

When handling tert-Butyl carbamate, it is essential to use safety goggles and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if necessary. Consult the Safety Data Sheet for detailed handling procedures.

How is tert-Butyl carbamate packed and shipped?

Tech Serve Solutions expertly packs and ships tert-Butyl carbamate globally, adhering to all necessary regulations for chemical export. Please contact us for specific shipping details.

How can I request a quote or sample of tert-Butyl carbamate?

To request a quote or sample of tert-Butyl carbamate, please use the 'Request a Quote' or 'Request a Sample' buttons on our product page, or contact our sales team directly.