Methyl 5-bromopyridine-3-carboxylate
Methyl 5-bromopyridine-3-carboxylate (CAS: 29681-44-5) is a halogenated heterocyclic organic compound with the molecular formula C7H6BrNO2 and a molecular weight of 216.03 g/mol. Supplied at 97% assay, this chemical serves as a valuable building block in organic synthesis. It is primarily utilised as a substrate in palladium-catalyzed cross-coupling reactions, particularly for the arylation of enol ethers, facilitating the construction of complex molecular architectures.
- IUPAC
- 5-Bromopyridine-3-carboxylic acid methyl ester,5-Bromonicotinic acid methyl ester,Methyl 5-bromonicotinate
- Synonyms
- Methyl 5-bromonicotinate5-Bromonicotinic acid methyl ester5-Bromopyridine-3-carboxylic acid methyl ester
Palladium-Catalyzed Arylation
This compound acts as a substrate in palladium-catalyzed arylation reactions. It is specifically employed in the microwave-assisted arylation of acetone's TMS enol ether, enabling the formation of carbon-carbon bonds.
Organic Synthesis Building Block
As a functionalized pyridine derivative, it is a key intermediate in the synthesis of more complex heterocyclic compounds. Its bromine substituent allows for versatile functionalization via cross-coupling chemistry.
Research and Development
Utilised in academic and industrial research settings for the development of novel synthetic methodologies and the exploration of new chemical entities within pharmaceutical and materials science.
| Molecular weight | 216.03 |
|---|---|
| Empirical formula | C7H6BrNO2 |
| Assay | 97% |
| Application | Substrate used in a microwave-assisted, palladium-catalyzed arylation of acetone as its TMS enol ether.1 |
| Melting point | 96-100 °C |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 5-bromopyridine-3-carboxylate used for?
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Methyl 5-bromopyridine-3-carboxylate (CAS: 29681-44-5) is used as a building block in organic synthesis, particularly as a substrate in palladium-catalyzed arylation reactions.
What is the CAS number and molecular formula?
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The CAS number is 29681-44-5 and the molecular formula is C7H6BrNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 5-bromopyridine-3-carboxylate at an assay of 97%. This product is intended for research and technical applications and is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should Methyl 5-bromopyridine-3-carboxylate be handled safely?
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This compound is classified as a danger with hazards H315 (Causes skin irritation), H318 (Causes serious eye damage), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves. Ensure good ventilation.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions offers global export services for its chemical products, adhering to international shipping regulations. Packaging is designed to ensure product integrity and safety during transit.
How can I request a sample or quote?
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To request a sample or a quote for Methyl 5-bromopyridine-3-carboxylate, please contact our sales department via the website or provided contact details, specifying your requirements.
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