5-fluoroorotic acid
5-Fluoroorotic acid (5-FOA; CAS 703-95-7) is a fluorinated pyrimidine carboxylic acid with the molecular formula C5H3FN2O4 and a molar mass of 174.09 g/mol. Supplied as a crystalline solid, it is a heterocyclic fluorinated building block used in organic and pharmaceutical synthesis and, most notably, as a selective agent in yeast and fungal molecular-biology screening. Tech Serve Solutions supplies and exports 5-fluoroorotic acid to research, fine-chemical and life-science customers worldwide.
- Synonyms
- 5-Fluoroorotic acid5-FOA5-Fluoro-orotic acid5-Fluoro-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid2,6-dihydroxy-5-fluoropyrimidine-4-carboxylic acid5-Fluorouracil-6-carboxylic acidCAS 703-95-7
Fluorinated pyrimidine building block
Serves as a fluorinated heterocyclic intermediate for the synthesis of pyrimidine derivatives and related fine chemicals. The orotic-acid scaffold and ring fluorine make it a useful starting point in medicinal-chemistry and exploratory synthesis.
Selective agent in yeast and fungal genetics
5-FOA is widely used in molecular biology to counter-select against cells expressing a functional URA3 (or equivalent) gene, since such cells convert it to a toxic product. This makes it a standard reagent for plasmid shuffling and marker-recycling experiments.
Laboratory reagent and reference material
Used as a research reagent and characterised reference compound in analytical and method-development work. Its defined identity (CAS 703-95-7, C5H3FN2O4) supports reproducible laboratory use.
Heterocyclic chemistry research
Applied in academic and industrial studies of fluorinated heterocycles and pyrimidine chemistry, where the combination of carboxylic acid, amide and fluorine functionality is of interest for further derivatisation.
| Molecular weight | 174.09 |
|---|---|
| Empirical formula | C5H3FN2O4 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-fluoroorotic acid used for?
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5-Fluoroorotic acid is used as a fluorinated pyrimidine building block in organic and pharmaceutical synthesis and as a laboratory reagent. It is best known in molecular biology as a selective (counter-selection) agent in yeast and fungal genetic screening, for example with URA3-based marker systems.
What is the CAS number and molecular formula of 5-fluoroorotic acid?
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The CAS number of 5-fluoroorotic acid is 703-95-7 and its molecular formula is C5H3FN2O4, with a molecular weight of 174.09 g/mol. Its EC number is 211-876-0. It is also known as 5-FOA.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-fluoroorotic acid as a research/reagent-grade fine chemical, with assay and full specifications confirmed on the certificate of analysis for each batch. We do not represent it as USP, BP or EP pharmacopoeial grade; exact purity is provided on request and stated on the documentation accompanying each consignment.
What are the safety and handling requirements for 5-fluoroorotic acid?
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5-Fluoroorotic acid is classified GHS07 with the signal word Warning. The hazard statements are H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Avoid dust formation, wear suitable gloves and eye protection (P261, P305+P351+P338), and consult the SDS before handling. It is assigned WGK 3 (high hazard to water) in Germany, so prevent release to drains and watercourses.
How is 5-fluoroorotic acid packed, shipped and exported?
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5-Fluoroorotic acid is packed as a solid in sealed, clearly labelled containers sized to the order, from gram quantities upward, with full documentation and an SDS. Tech Serve Solutions handles export logistics and country-specific compliance, shipping to research and industrial customers worldwide.
How do I request a sample or quote for 5-fluoroorotic acid?
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Contact Tech Serve Solutions with your required quantity, purity and delivery destination, and our team will respond with availability, lead time and documentation. Samples can be arranged where appropriate to support your evaluation and qualification.
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