tert-Butyl 12-amino-4,7,10-trioxadodecanoate
Tert-Butyl 12-amino-4,7,10-trioxadodecanoate (CAS: 252881-74-6), with a molecular formula of C13H27NO5 and a molecular weight of 277.36 g/mol, is a functionalized oligoethylene glycol derivative. It serves as a valuable building block in chemical synthesis and chemical biology. This compound is commonly employed in the development of PEGylated molecules and in various research applications requiring polyethylene glycol functionalities.
- IUPAC
- tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate
- Synonyms
- 252881-74-6, C13H27NO5, tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate

Chemical Synthesis
This compound acts as a versatile intermediate in organic synthesis. Its amino and ester functionalities, along with the oligoethylene glycol chain, allow for diverse chemical modifications and conjugations.
PEGylation
Utilised for introducing polyethylene glycol (PEG) chains onto other molecules, such as proteins or small molecules, to improve solubility, stability, and pharmacokinetic profiles in drug development.
Chemical Biology Research
Serves as a reagent in chemical biology for creating modified biomolecules or probes. Its structure is useful for studying biological processes or for targeted delivery systems.
Functionalized Oligoethylene Glycols
As a derivative of oligoethylene glycol, it can be used to create specialised reagents with tailored properties for various biochemical and material science applications.
| Molecular weight | 277.36 |
|---|---|
| Empirical formula | C13H27NO5 |
| Assay | ≥80% (T) |
| Grade | technical |
| Storage temperature | −20°C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 169 °C / 336.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyl 12-amino-4,7,10-trioxadodecanoate used for?
+
This compound is used in chemical synthesis, for PEGylation applications, and in chemical biology research as a functionalized oligoethylene glycol building block.
What are the CAS number and molecular formula?
+
The CAS number is 252881-74-6 and the empirical formula (Hill notation) is C13H27NO5.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this chemical in technical grade with an assay of ≥80% (T). We do not represent this product as USP, BP, or EP grade.
How should tert-Butyl 12-amino-4,7,10-trioxadodecanoate be handled safely?
+
This compound is a Warning substance (GHS07) with hazards H315, H319, and H335. It causes skin irritation, serious eye irritation, and may cause respiratory irritation. Use appropriate personal protective equipment, including eyeshields and suitable gloves, and ensure adequate ventilation. Avoid breathing vapours or dust.
How is this chemical packed and shipped?
+
Products are packed according to international shipping regulations. Please contact us for specific export or bulk quantity details.
How can I request a sample or quote?
+
To request a sample or a quote, please contact our sales department via the website or by phone, providing your specific requirements.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis