Strychnine
Strychnine (CAS 57-24-9, C21H22N2O2) is a highly toxic alkaloid with a molecular weight of 334.41 g/mol. It is primarily known for its potent, irreversible inhibition of glycine and GABA receptors, acting as a powerful antagonist. Historically used as a pesticide, it is now mainly employed in research settings for neuropharmacological studies and as a chiral resolving agent in asymmetric synthesis.
- IUPAC
- (−)-Strychnine
- Synonyms
- (-)-Strychnine
Neuroscience Research
Strychnine serves as a crucial tool in neuroscience to study the function of glycine and GABA receptors, key inhibitory neurotransmitter systems in the central nervous system. Researchers utilise its antagonist properties to investigate neural pathways and receptor mechanisms.
Asymmetric Synthesis
As a chiral alkaloid, strychnine and its derivatives are employed as chiral resolving agents or catalysts in stereoselective synthesis. They facilitate the separation of enantiomers or the creation of specific stereoisomers in organic chemistry.
Biochemical Probe
Its specific interaction with ion channels and neurotransmitter receptors makes strychnine a valuable biochemical probe for understanding receptor binding sites and signalling pathways.
| Molecular weight | 334.41 |
|---|---|
| Empirical formula | C21H22N2O2 |
| Solubility | chloroform: soluble, clear to hazy |
| Melting point | 284-286 °C(lit.) |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P264Wash thoroughly after handling
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1692 6.1/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+,N |
| Risk statements (R) | 27/28-50/53 |
| Safety statements (S) | 36/37-45-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Strychnine used for?
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Strychnine is primarily used in neuroscience research as an antagonist for glycine and GABA receptors and in asymmetric synthesis as a chiral resolving agent. Historically, it was used as a pesticide, but this application is now restricted due to its extreme toxicity.
What is the CAS number and chemical formula for Strychnine?
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The CAS number for Strychnine is 57-24-9, and its chemical formula is C21H22N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Strychnine for research and laboratory use. The specific assay and grade are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, EP, or for nutraceutical, food, or pharmaceutical use.
How should Strychnine be handled?
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Strychnine is extremely toxic (Danger, H300, H310, H410). Handle with extreme caution using appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure handling occurs in a well-ventilated area or fume hood, and prevent release into the environment (N).
Is Strychnine a controlled substance?
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Strychnine is subject to strict regulations due to its toxicity and potential for misuse. While not typically scheduled as a narcotic, its sale and use are controlled in many jurisdictions. Please consult your local regulations.
How is Strychnine packed and shipped?
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Strychnine is packed and shipped according to UN 1692, Class 6.1 (Toxic substances), Packing Group I, adhering to strict international regulations for hazardous materials transport.
How can I request a sample or quote for Strychnine?
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To request a sample or quote for Strychnine, please contact our sales team through the website or by calling us directly. Provide the product name and CAS number (57-24-9) for prompt service.
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