Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt
Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt (CAS: 82436-77-9), with the molecular formula C16H18N2Na2O14S2 and a molecular weight of 572.43 g/mol, is a water-soluble, homobifunctional cross-linking reagent. It is designed to react with primary amines at physiological pH, forming stable amide bonds. This compound is valuable in chemical biology and synthesis for creating conjugates, modifying proteins, and studying protein interactions and structures.
- IUPAC
- BS3,Bis(sulfosuccinimidyl) suberate sodium salt
- Synonyms
- BS3Bis(sulfosuccinimidyl) suberate sodium salt
Homobifunctional Crosslinking
This reagent facilitates the covalent linking of two molecules that possess primary amine groups. It is particularly useful for preparing stable conjugates between proteins, antibodies, or other biomolecules.
Protein Conjugation
Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt is employed to conjugate proteins to carrier molecules, haptens, or other proteins. The reaction occurs efficiently with primary amines at pH 7.5, forming amide bonds.
Bioconjugation Chemistry
Its water solubility and amine reactivity make it suitable for various bioconjugation applications in molecular biology and proteomics research, including structural analysis and interaction studies.
Receptor-Ligand Studies
This crosslinker can be used to study receptor-ligand interactions by covalently linking them together, aiding in the characterisation of binding events and complex formation.
| Molecular weight | 572.43 |
|---|---|
| Empirical formula | C16H18N2Na2O14S2 |
| Assay | ≥95% (H-NMR) |
| Form | powder |
| Solubility | H2O: soluble10 mg/mLDMF: soluble |
| Storage temperature | −20°C |
| Application | Water soluble, homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Useful for preparation of protein-protein, receptor-ligand and hapten carrier molecule conjugates. Incorporates 8-atom linker. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt used for?
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It is a water-soluble, homobifunctional cross-linking reagent used primarily in chemical biology and synthesis for applications such as protein-protein conjugation, preparation of receptor-ligand conjugates, and protein structural analysis.
What are the CAS number and formula for this product?
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The CAS number is 82436-77-9, and the empirical formula (in Hill notation) is C16H18N2Na2O14S2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a PREMIUM quality level with an assay of ≥95% (H-NMR). We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should this chemical be handled and stored?
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Handle with appropriate personal protective equipment. It is classified as a warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Store at -20°C.
How is this product shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and can arrange for the packed and shipped export of this product according to your specific requirements and destination regulations.
How can I request a quote or sample?
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Please contact our sales team through the website or your designated account manager to request a quote or to arrange for a sample.
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