2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride
2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride (CAS: 154445-78-0) is a versatile chemical intermediate with the molecular formula C13H17ClO3S. This compound is primarily utilised in chemical synthesis, particularly in peptide chemistry for guanidine protection and guanidinylation. Its specific structure lends itself to applications within chemical biology research, facilitating the development of novel molecules and research tools.
- IUPAC
- Pbf-Cl
- Synonyms
- 6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chlorideC13H17ClO3SPbf-Cl
Guanidine Protection and Guanidinylation
This sulfonyl chloride derivative is effective for introducing protecting groups onto guanidine functionalities. It serves as a reagent in synthesising peptides and other biomolecules where selective protection of guanidino groups is required.
Chemical Synthesis Intermediate
The compound acts as a valuable building block in complex organic synthesis. Its reactive sulfonyl chloride group allows for facile derivatisation, enabling the construction of various target molecules in research and development settings.
Chemical Biology Research
Utilised in studies exploring biological pathways and molecular interactions, this chemical can be employed in the synthesis of specialised probes or modified biomolecules for research purposes.
| Molecular weight | 288.79 |
|---|---|
| Empirical formula | C13H17ClO3S |
| Assay | ≥95.0% (AT) |
| Storage temperature | 2-8°C |
| Melting point | 69-71 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride used for?
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This compound is primarily used as a reagent for guanidine protection and guanidinylation in peptide chemistry, and as an intermediate in general chemical synthesis and chemical biology research.
What is the CAS number and molecular formula for 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride?
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The CAS number is 154445-78-0 and the molecular formula is C13H17ClO3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride with a purity of ≥95.0% (AT). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride be handled?
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This compound is corrosive and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (type N100 or P3). Store at 2-8°C.
How is this chemical shipped and exported?
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According to UN 3261, 8 / PGIII classification, the chemical is shipped as a corrosive solid. Tech Serve Solutions is an experienced global exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a sample or quote for this product?
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Please contact our sales team directly through the website to request a sample or a quotation for 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride.
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