SKF-86002
SKF-86002 (CAS: 72873-74-6) is an off-white solid chemical compound with the molecular formula C16H12N3FS and a molecular weight of 297.35 g/mol. This substance is recognised for its role as a potent inhibitor, particularly in cell signalling pathways. It is widely utilised in biochemical research for investigating kinase activity and cellular responses to inflammatory stimuli.
- IUPAC
- 6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
Protein Kinase Inhibition Research
SKF-86002 serves as a selective inhibitor of certain protein kinases, making it valuable for studying signal transduction pathways involved in cellular processes and disease.
Cellular Signalling Studies
This compound is employed in cell biology research to investigate the roles of specific kinases in cellular responses, such as inflammation, by modulating their activity.
Biochemical Assays
SKF-86002 is used as a reagent in biochemical assays to understand enzyme kinetics and inhibitor efficacy, contributing to drug discovery and development.
| Molecular weight | 297.35 |
|---|---|
| Empirical formula | C16H12N3FS |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | off-white |
| Solubility | DMSO: soluble >10 mg/mL |
| Storage temperature | 2-8°C |
| Melting point | 189-190 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... IL1B(3553), TNF(7124)rat ... Alox5(25290) |
|---|---|
| Storage Condition | protect from light |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SKF-86002 used for?
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SKF-86002 is primarily used in research for studying protein kinase inhibition and cellular signalling pathways, particularly in investigating inflammatory responses and kinase activity.
What is the CAS number and chemical formula for SKF-86002?
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The CAS number for SKF-86002 is 72873-74-6, and its empirical formula is C16H12N3FS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SKF-86002 with a purity of ≥98% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should SKF-86002 be handled and stored?
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SKF-86002 is classified as a Warning substance, with hazard statements H315, H319, and H335, indicating it can cause skin irritation, serious eye irritation, and respiratory irritation. Appropriate personal protective equipment includes a dust mask (N95 US type), eyeshields, and gloves. Store at 2-8°C and protect from light.
How is SKF-86002 packed and shipped?
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SKF-86002 is supplied as an off-white solid. We ensure secure and compliant packaging for global export, adhering to international shipping regulations for research chemicals.
How can I request a sample or quote for SKF-86002?
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To request a sample or obtain a quote for SKF-86002, please contact our sales department through the website or direct email, providing your research requirements and shipping details.
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