(S)-(+)-Mephenytoin
(S)-(+)-Mephenytoin (CAS 70989-04-7) is a chemical compound with the formula C12H14N2O2 and a molecular weight of 218.25 g/mol. This off-white solid is primarily utilized in biochemical research as a substrate for studying cytochrome P450 metabolism, particularly the CYP2C19 enzyme. It also serves as a probe substrate in analytical techniques like LC/MS for assessing relative activity factors, contributing to a deeper understanding of drug metabolism and xenobiotic interactions.
- IUPAC
- (S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione,(S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin
CYP2C19 Substrate in Metabolic Studies
S-Mephenytoin is employed as a verified substrate for the CYP2C19 enzyme, enabling researchers to investigate cytochrome P450-mediated drug metabolism and enzyme activity. This application is crucial for understanding how the body processes various compounds.
LC/MS Analysis of Enzyme Activity
This compound serves as a probe substrate in Liquid Chromatography-Mass Spectrometry (LC/MS) based analyses. It is used to determine the relative activity factor (RAF) of enzymes, providing quantitative insights into metabolic pathways and drug interactions.
Research in Drug and Xenobiotic Metabolism
As a well-defined substrate, (S)-(+)-Mephenytoin aids in the study of drug and xenobiotic metabolism. Its use helps elucidate complex biochemical pathways and the factors influencing compound clearance within biological systems.
| Molecular weight | 218.25 |
|---|---|
| Empirical formula | C12H14N2O2 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | off-white |
| Solubility | DMSO: soluble |
| Storage temperature | 2-8°C |
| Melting point | 135-138 °C |
| Application | S-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism1. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF)2. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-Mephenytoin used for?
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(S)-(+)-Mephenytoin is used as a research chemical, specifically as a substrate for studying cytochrome P450 (CYP2C19) metabolism and in LC/MS-based analysis of relative activity factors.
What is the CAS number and chemical formula for (S)-(+)-Mephenytoin?
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The CAS number for (S)-(+)-Mephenytoin is 70989-04-7, and its empirical formula (Hill notation) is C12H14N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-(+)-Mephenytoin with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product data.
What are the safety and handling recommendations for (S)-(+)-Mephenytoin?
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(S)-(+)-Mephenytoin is classified as a Warning (GHS07) and may cause harm if swallowed (H302), skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn. Ensure adequate ventilation and avoid inhaling dust. Consult the Safety Data Sheet for full details.
How is (S)-(+)-Mephenytoin packaged and shipped?
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This product is typically supplied as an off-white solid and stored at 2-8°C. TSS exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally, adhering to all relevant shipping regulations.
How can I request a quote or sample for (S)-(+)-Mephenytoin?
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To request a quote or a sample of (S)-(+)-Mephenytoin, please visit the Tech Serve Solutions website or contact our sales department directly.
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