(S)-(−)-Warfarin
(S)-(−)-Warfarin (CAS: 5543-57-7), a chiral coumarin derivative with the molecular formula C19H16O4 and a molecular weight of 308.33 g/mol, is a white to pale yellow solid. It is primarily utilised in biochemical research, particularly in studies concerning drug metabolism and cell signalling. Its defined stereochemistry makes it valuable for investigating enzyme specificities and cellular responses in various biological systems.
- IUPAC
- S-(−)-3-Acetonybenzyl)-4-hydroxycoumarin,S-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
- Synonyms
- S-(−)-3-Acetonybenzyl)-4-hydroxycoumarinS-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
Drug Metabolism Studies
Used in research to investigate the induction of hepatic enzymes like CYP3A4 and CYP2C by specific drug candidates. This helps in understanding metabolic pathways and potential drug-drug interactions.
Cell Biology Research
Applied in cell-based assays, such as in HepG2 cells, to study protein profiles and cellular responses to xenobiotics. This aids in understanding cellular mechanisms and toxicity.
Biochemical Pathway Investigation
Its specific stereochemistry allows for detailed studies into enzyme active sites and substrate specificity within metabolic pathways. It serves as a tool for understanding biological processes at a molecular level.
| Molecular weight | 308.33 |
|---|---|
| Empirical formula | C19H16O4 |
| Assay | ≥97% (HPLC) |
| Colour | white to pale yellow |
| Storage temperature | 2-8°C |
| Application | Studies using (R)-(+)-warfarin have reported that it can upregulate hepatic CYP3A4 and CYP2C1. It has also been used in HepG2 cells to study protein profiles2. |
| Melting point | ≥170 °C |
Hazard statements
- H360D
- H372Causes damage to organs through prolonged exposure
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P201Obtain special instructions before use
- P273Avoid release to the environment
- P308IF exposed or concerned
| Transport (UN / ADR) | UN 2811 6.1 / PGI |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-48/25-52/53 |
| Safety statements (S) | 53-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CYP2C9(1559) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-Warfarin used for?
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(S)-(−)-Warfarin is used in biochemical research for studies involving drug metabolism, cell signalling, and the investigation of enzyme specificities, particularly in relation to CYP3A4 and CYP2C pathways.
What are the CAS number and formula for (S)-(−)-Warfarin?
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The CAS number for (S)-(−)-Warfarin is 5543-57-7, and its empirical formula is C19H16O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-(−)-Warfarin with an assay of ≥97% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade; it is intended for research and laboratory use.
How should (S)-(−)-Warfarin be handled safely?
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(S)-(−)-Warfarin is classified as dangerous. It can cause severe damage to health by radiation during pregnancy, and damage to organs through prolonged or repeated exposure. It is also harmful to aquatic life with long lasting effects. Handle with appropriate personal protective equipment in a well-ventilated area, and avoid release into the environment. Always consult the Safety Data Sheet (SDS) before use.
How is (S)-(−)-Warfarin packed and shipped?
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(S)-(−)-Warfarin is packed according to industry standards for chemical safety and stability. It is available for export globally by Tech Serve Solutions, adhering to all relevant shipping regulations for hazardous materials.
How can I request a sample or quote for (S)-(−)-Warfarin?
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To request a sample or a quote for (S)-(−)-Warfarin, please contact our sales department through the TSS website or by phone. Please specify the required quantity and your delivery location.
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